ArticleInternational journal of nanomedicine2008
Human-derived nanoparticles and vascular response to injury in rabbit carotid arteries: proof of principle.
Article in International journal of nanomedicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical implications of calcifying nanoparticles in dental diseases: a critical review.International journal of nanomedicine · 2014Pooled it
- Calciprotein Particles: Balancing Mineral Homeostasis and Vascular Pathology.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- [Current concepts on the pathogenesis of urinary stones].Der Urologe. Ausg. A · 2019Review
- Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells.Nanoscale research letters · 2014Article
- Calcifying nanoparticles: one face of distinct entities?Frontiers in microbiology · 2014Article
- Cytotoxicity and apoptosis induced by nanobacteria in human breast cancer cells.International journal of nanomedicine · 2014Article
- New insights into the pathogenesis of renal calculi.The Urologic clinics of North America · 2013Review
- Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.PloS one · 2013Article
- The role of calcifying nanoparticles in biology and medicine.International journal of nanomedicine · 2012Review
- Key role of alkaline phosphatase in the development of human-derived nanoparticles in vitro.Acta biomaterialia · 2011Article
- Calcium-based nanoparticles accelerate skin wound healing.PloS one · 2011Article
- Proteomic evaluation of biological nanoparticles isolated from human kidney stones and calcified arteries.Acta biomaterialia · 2010Article
- Article
- Review
- Characterization of biofilm formed by human-derived nanoparticles.Nanomedicine (London, England) · 2009Article
- Article
- Biologic nanoparticles and platelet reactivity.Nanomedicine (London, England) · 2009Article
- Systemic injection of planktonic forms of mammalian-derived nanoparticles alters arterial response to injury in rabbits.American journal of physiology. Heart and circulatory physiology · 2009Article
- Article
- Putative nanobacteria represent physiological remnants and culture by-products of normal calcium homeostasis.PloS one · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Self-calcifying, self-replicating nanoparticles have been isolated from calcified human tissues. However, it is unclear if these nanoparticles participate in disease processes. Therefore, this study was designed to preliminarily test the hypothesis that human-derived nanoparticles are causal to arterial disease processes. One carotid artery of 3 kg male rabbits was denuded of endothelium; the contralateral artery remained unoperated as a control. Each rabbit was injected intravenously with either saline, calcified, or decalcified nanoparticles cultured from calcified human arteries or kidney stones. After 35 days, both injured and control arteries were removed for histological examination. Injured arteries from rabbits injected with saline showed minimal, eccentric intimal hyperplasia. Injured arteries from rabbits injected with calcified kidney stone- and arterial-derived nanoparticles occluded, sometimes with canalization. The calcified kidney stone-derived nanoparticles caused calcifications within the occlusion. Responses to injury in rabbits injected with decalcified kidney stone-derived nanoparticles were similar to those observed in saline-injected animals. However, decalcified arterial-derived nanoparticles produced intimal hyperplasia that varied from moderate to occlusion with canalization and calcification. This study offers the first evidence that there may be a causal relationship between human-derived nanoparticles and response to injury including calcification in arteries with damaged endothelium.
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