ReviewClinical interventions in aging2008
New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor.
Review in Clinical interventions in aging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Association between serum level of C-reactive protein and risk of cardiovascular events based on cohort studies.Journal of human hypertension · 2021Pooled it
- The possible modulatory impact of high-dose statin therapy on carotid intima-media thickness: a preliminary study.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2024Article
- Role of C-Reactive Protein, An Inflammatory Biomarker in The Development of Atherosclerosis and Its Treatment.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024Review
- A Nomogram for Predicting Patent Foramen Ovale-Related Stroke Recurrence.Frontiers in neurology · 2022Article
- Cardiovascular Disease Prediction by Machine Learning Algorithms Based on Cytokines in Kazakhs of China.Clinical epidemiology · 2021Article
- Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits.Frontiers in immunology · 2020Review
- EFFECTS OF OCCUPATIONAL STRESS ON THE ACTIVATION OF HEMOSTATIC AND INFLAMMATORY SYSTEM.Acta clinica Croatica · 2019Article
- Index C-reactive protein predicts increased severity in acute sigmoid diverticulitis.Therapeutics and clinical risk management · 2018Article
- Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis.Mediators of inflammation · 2016Article
- Antioxidant and anti-inflammatory effects of flavocoxid in high-cholesterol-fed rabbits.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Six-year change in high-sensitivity C-reactive protein and risk of diabetes, cardiovascular disease, and mortality.American heart journal · 2015Article
- Subclinical hypothyroidism is associated with elevated high-sensitive C-reactive protein among adult Taiwanese.Endocrine · 2013Article
- Update on the Pathophysiological Role of Intracellular Signaling Pathways in Atherosclerotic Plaques and Ischemic Myocardium.Current signal transduction therapy · 2012Article
- Inflammatory cardiovascular risk biomarkers: update on novelties and limitations.Mediators of inflammation · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory processes are orchestrated by several soluble molecules, which interact with cell populations involved. Cytokines, chemokines, acute-phase reactants, and hormones are crucial in the evolution of several inflammatory disorders, such as atherosclerosis. Several evidences suggest that C-reactive protein (CRP) started to be considered as a cardiovascular risk factor, since CRP directly induces atheroslerosis development. The recent demonstration of CRP production not only by the liver, but also within atherosclerotic plaques by activated vascular cells, also suggests a possible dual role, as both a systemic and tissue agent. Although more studies are needed, some therapeutic approaches to reduce CRP levels have been performed with encouraging results. However, given the strong limitations represented by its low specificity and still accordingly with the American Heart Association, there is no need for high sensitivity CRP screening of the entire adult population as a public-health measure. The measure of serum CRP might be useful only for patients who are considered at intermediate risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.