ArticleMedical oncology (Northwood, London, England)2009
Cytokine concentrations are not predictive of bacteremia in febrile neutropenic patients.
Article in Medical oncology (Northwood, London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy.Scientific reports · 2022Article
- Pro-inflammatory cytokine ratios determine the clinical course of febrile neutropenia in children receiving chemotherapy.Molecular and cellular pediatrics · 2020Article
- Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).Annals of hematology · 2017Review
- Biomarker candidates for the detection of an infectious etiology of febrile neutropenia.Infection · 2016Article
- Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation.BMC cancer · 2015Article
- Intensive serial biomarker profiling for the prediction of neutropenic Fever in patients with hematologic malignancies undergoing chemotherapy: a pilot study.Hematology reports · 2014Article
- Use of inflammatory molecules to predict the occurrence of fever in onco-hematological patients with neutropenia.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Observational
- Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients.Clinics (Sao Paulo, Brazil) · 2011Article
- C-reactive protein in critically ill cancer patients with sepsis: influence of neutropenia.Critical care (London, England) · 2011Article
- Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor.Intensive care medicine · 2010Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assay of cytokines and C reactive protein (CRP) in different periods of febrile neutropenia may be helpful for early defining the risk in severe infections. We determined serum interleukin-6 (IL-6), interleukin-8 (IL-8), soluble interleukin-2 receptor (sIL-2R), tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and CRP in 22 previously untreated patients with various malignancies. Samples were obtained in four different clinical periods of febrile neutropenia; prior to chemotherapy, afebrile neutropenic period after chemotherapy, febrile neutropenic period, and recovery period. When compared to sex-and age-matched group of healthy subjects, IL-6, IL-8, sIL-2R, and CRP levels were found to be elevated in all periods. The highest levels were encountered in the febrile neutropenic period. For predictivity purposes, the afebrile neutropenic period was the most important period. Serum sIL-2R, IL-6, IL-8 and CRP levels were elevated in this period. IL-8 levels showed the most stable elevation through different stages of febrile neutropenia. Serum IL-8 levels were found to have the most reliable and stable elevation in different clinical stages of febrile neutropenia. Nevertheless, IL-8 is not able to discriminate among risk groups and cannot be used as a predictive factor.
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