ArticleBreast cancer research and treatment2009
Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis.
Article in Breast cancer research and treatment, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma.Haematologica · 2013Trial
- Unveiling the oncogenic role of LZTS1 in colorectal cancer.Journal of cellular and molecular medicine · 2024Article
- Article
- Application of an open-chamber multi-channel microfluidic device to test chemotherapy drugs.Scientific reports · 2020Article
- The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia.Cancers · 2019Article
- Precise pathologic diagnosis and individualized treatment improve the outcomes of invasive micropapillary carcinoma of the breast: a 12-year prospective clinical study.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Epigenetic silencing ofOncotarget · 2018Article
- Loss of Leucine Zipper Putative Tumor Suppressor 1 (LZTS1) Expression Contributes to Lymph Node Metastasis of Breast Invasive Micropapillary Carcinoma.Pathology oncology research : POR · 2015Article
- Promoter hypermethylation profiling of distant breast cancer metastases.Breast cancer research and treatment · 2015Article
- LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer.Oncotarget · 2014Article
- Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer.Oncotarget · 2014Article
- Cytosine 5-Hydroxymethylation of the LZTS1 Gene Is Reduced in Breast Cancer.Translational oncology · 2013Article
- MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1.Nature communications · 2013Article
- Article
- A comprehensive information database (CID) of breast cancer patients in China.Frontiers of medicine · 2012Article
- Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer.Breast cancer research : BCR · 2012Article
- Possibility of the use of public microarray database for identifying significant genes associated with oral squamous cell carcinoma.Genomics & informatics · 2012Article
- Genomic imbalances in esophageal carcinoma cell lines involve Wnt pathway genes.World journal of gastroenterology · 2011Article
- Tumor suppressor genes are frequently methylated in lymph node metastases of breast cancers.BMC cancer · 2010Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
FEZ1/LZTS1 is a tumor suppressor gene located in chromosomal band 8p22, and methylation has been identified as a mechanism for its loss of function in tumors. Chromosomal deletion at 8p22 is also frequent in breast cancer. We therefore examined whether LZTS1 plays a role in breast cancer. We analyzed expression of LZTS1 at both the RNA and protein levels, and promoter methylation in a number of primary tumors and cell lines from breast cancer. We also examined the association between LZTS1 expression and different clinicopathological parameters of breast cancer. We found that the expression of LZTS1 mRNA was reduced in 25 of 50 (50%) primary tumors and 29 of 30 (97%) breast cancer cell lines. Immunohistochemical staining showed that LZTS1 protein was absent or down-regulated in 72 (72%) of 100 primary breast carcinomas. Reduced expression of LZTS1 at either the RNA or protein level was significantly correlated with lymph node metastases (P < 0.05). DNA methylation analysis revealed that the LZTS1 gene was frequently methylated in both cell lines and primary tumors from breast cancer, and the extent of DNA methylation was correlated with reduced expression of the gene. These findings suggest that LZTS1 plays a role in the development and progression of breast cancer at least through promoter methylation-mediated transcriptional downregulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.