ReviewJournal of anesthesia2008
Anesthetics, immune cells, and immune responses.
Review in Journal of anesthesia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 129 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combined Anesthesia Considerations in Uro-Genital Robot Assisted Laparoscopic Surgeries: Acute Kidney Injury
A Randomized, Open-label Study to Compare Propofol Anesthesia With Sevoflurane Anesthesia in Terms of Overall Survival in Patients With Surgical Intervention for Either Breast-, Colon- or Rectal Cancer
Effect of a Perioperative Opioid Free Anaesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response and Immunomodulation in Elective VATS Lobectomy for NSCLC Lung Cancer: A Prospective Randomized Study
Who cites it
129 citing papers in PubMed, 3 syntheses or guidelines pooled it, 366 citations in OpenAlex.
- Effect of different anaesthetic techniques on the prognosis of patients with colorectal cancer after resection: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Anti-inflammatory Effects of Perioperative Dexmedetomidine Administered as an Adjunct to General Anesthesia: A Meta-analysis.Scientific reports · 2015Pooled it
- Anaesthetic techniques for risk of malignant tumour recurrence.The Cochrane database of systematic reviews · 2014Pooled it
- Suppressive effects of deep balanced anesthesia on cellular immunity and protein expression: a randomized-controlled pilot study.BMC anesthesiology · 2025Trial
- The immunosuppressive effects of volatile versus intravenous anesthesia combined with epidural analgesia on kidney cancer: a pilot randomized controlled trial.Korean journal of anesthesiology · 2020Trial
- The influence of dexmedetomidine and propofol on circulating cytokine levels in healthy subjects.BMC anesthesiology · 2019Trial
- Combined anesthesia shows better curative effect and less perioperative neuroendocrine disorder than general anesthesia in early stage NSCLC patients.The Journal of international medical research · 2019Trial
- Trial
- Trial
- Effect of single-dose dexmedetomidine on postoperative recovery after ambulatory ureteroscopy and ureteric stenting: a double blind randomized controlled study.BMC anesthesiology · 2018Trial
- Effect of propofol and sevoflurane on the inflammatory response of patients undergoing craniotomy.BMC anesthesiology · 2016Trial
- A comparison of the immunological effects of propofol and isoflurane for maintenance of anesthesia in healthy dogs.The Journal of veterinary medical science · 2015Trial
- Trial
- Inflammatory response after open and laparoscopic Nissen fundoplication in children: a randomized study.Pediatric surgery international · 2014Trial
- Comparison of inflammatory cytokine profiles in plasma of patients undergoing otorhinological surgery with propofol or isoflurane anesthesia.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Trial
- Comparative effects of flurbiprofen and fentanyl on natural killer cell cytotoxicity, lymphocyte subsets and cytokine concentrations in post-surgical intensive care unit patients: prospective, randomized study.Journal of anesthesia · 2013Trial
- Immunomodulatory effects of total intravenous and balanced inhalation anesthesia in patients with bladder cancer undergoing elective radical cystectomy: preliminary results.Journal of experimental & clinical cancer research : CR · 2013Trial
- The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery.Journal of neurosurgical anesthesiology · 2013Trial
- A therapeutic dose of ketoprofen causes acute gastrointestinal bleeding, erosions, and ulcers in rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2012Trial
- Effects of anesthetic methods on preserving anti-tumor T-helper polarization following hepatectomy.World journal of gastroenterology · 2012Trial
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
General anesthesia accompanied by surgical stress is considered to suppress immunity, presumably by directly affecting the immune system or activating the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Along with stress such as surgery, blood transfusion, hypothermia, hyperglycemia, and postoperative pain, anesthetics per se are associated with suppressed immunity during perioperative periods because every anesthetic has direct suppressive effects on cellular and neurohumoral immunity through influencing the functions of immunocompetent cells and inflammatory mediator gene expression and secretion. Particularly in cancer patients, immunosuppression attributable to anesthetics, such as the dysfunction of natural killer cells and lymphocytes, may accelerate the growth and metastases of residual malignant cells, thereby worsening prognoses. Alternatively, the anti-inflammatory effects of anesthetics may be beneficial in distinct situations involving ischemia and reperfusion injury or the systemic inflammatory response syndrome (SIRS). Clinical anesthesiologists should select anesthetics and choose anesthetic methods with careful consideration of the clinical situation and the immune status of critically ill patients, in regard to long-term mortality, morbidity, and the optimal prognosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.