ArticleWorld journal of surgery2008
Surgical margin status and prognosis of gastrointestinal stromal tumor.
Article in World journal of surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparison of Prognosis Between Microscopically Positive and Negative Surgical Margins for Primary Gastrointestinal Stromal Tumors: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2022Pooled it
- Prognostic role of microscopically positive margins for primary gastrointestinal stromal tumors: a systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Clinical outcomes and functional analysis of third space robotic and endoscopic cooperative surgery versus laparoscopic wedge resection for gastric submucosal tumours: a propensity score-matched study.Updates in surgery · 2022Article
- Positive microscopic surgical margins: Is there an association with survival in resected small gastrointestinal stromal tumors?American journal of surgery · 2021Article
- Microscopic positive tumor margin does not increase the rate of recurrence in endoscopic resected gastric mesenchymal tumors compared to negative tumor margin.Surgical endoscopy · 2020Article
- Is the Surgical Margin in Gastrointestinal Stromal Tumors Different?Visceral medicine · 2018Review
- Endoscopic resection of gastric gastrointestinal stromal tumors originating from the muscularis propria layer in North America: methods and feasibility data.Surgical endoscopy · 2018Article
- Radiotherapy for Gastrointestinal Stromal Tumors.Chinese medical journal · 2018Review
- Current treatment strategies in pediatric gastrointestinal stromal cell tumor.Translational gastroenterology and hepatology · 2018Review
- Prognostic role of tumor necrosis in patients undergoing curative resection for gastric gastrointestinal stromal tumor: a multicenter analysis of 740 cases in China.Cancer medicine · 2017Article
- Interpretation of Pathologic Margin after Endoscopic Resection of Gastrointestinal Stromal Tumor.Clinical endoscopy · 2016Review
- Long-term outcomes of combined endoscopic/laparoscopic intragastric enucleation of presumed gastric stromal tumors.Surgical endoscopy · 2016Article
- Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in sarcomatosis from gastrointestinal stromal tumor.The American surgeon · 2014Article
- Prognostic factors for primary gastrointestinal stromal tumours: are they the same in the multidisciplinary treatment era?Langenbeck's archives of surgery · 2014Article
- Surgical treatment of gastric gastrointestinal stromal tumor.Journal of gastric cancer · 2013Article
- Microscopically positive margins for primary gastrointestinal stromal tumors: analysis of risk factors and tumor recurrence.Journal of the American College of Surgeons · 2012Article
- Different sites and prognoses of gastrointestinal stromal tumors of the stomach: report of 187 cases.World journal of surgery · 2010Article
- Loss of RKIP expression is associated with poor survival in GISTs.Virchows Archiv : an international journal of pathology · 2009Article
- Small EUS-suspected gastrointestinal stromal tumors of the stomach: An overview for the current state of management.Endoscopic ultrasoundArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgery is the best treatment for primary GIST and may be curative, but resection extension/completeness impact on the prognosis remains controversial. The authors aim was to evaluate the clinicopathological (CP) parameters and surgical margins status influence on GIST patients' outcome. MATERIALS AND
methodsThe study evaluated 113 consecutive patients with sporadic GIST; the influence of CP parameters on recurrence-free survival (RFS) and disease-specific survival (DSS) was determined by univariate analysis (UA) and multivariate analysis (MA).
resultsOf 104 cases, macroscopically complete resection was achieved in 96: R0 surgical margin status in 78 and R1 in 18. Recurrence rates (12.5%) were significantly lower in R0 (9.0%) than in R1 (27.8%). Tumor > 10 cm, mitotic count > 5/50 high power field (HPF), and high-risk GIST predicted poor RFS and DSS (UA). Disease-specific survival was significantly shorter after macroscopic incomplete (R2) resection, for mixed cellular morphology, and in tumors with necrosis (UA). High-risk GIST (p = 0.016) and R2 resection (p = 0.013) predicted poor DSS of patients (MA).
conclusionsHigh risk and positive macroscopic surgical margin status are parameters associated with poor disease-specific survival in GIST patients.
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Registered trials
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