ArticleJournal of human genetics2008
Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia.
Article in Journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Clinical, cytogenetic, and molecular findings of isodicentric Y chromosomes.Molecular cytogenetics · 2019Article
- Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness.Molecular neuropsychiatry · 2015Article
- Profiling of hypothalamic and hippocampal gene expression in chronically stressed rats treated with St. John's wort extract (STW 3-VI) and fluoxetine.Psychopharmacology · 2011Article
- Genetics in schizophrenia: where are we and what next?Dialogues in clinical neuroscience · 2010Review
- Disruption of the neurexin 1 gene is associated with schizophrenia.Human molecular genetics · 2009Article
- Review
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Authors and funding
14 authors.
Funding
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Abstract
Schizophrenia is a common psychiatric disorder with a strong genetic contribution. Disease-associated chromosomal abnormalities in this condition may provide important clues, such as DISC1. In this study, 59 schizophrenia patients were analyzed by microarray comparative genomic hybridization (CGH) using custom bacterial artificial chromosome (BAC) microarray (4,219 BACs with 0.7-Mb resolution). Chromosomal abnormalities were found in six patients (10%): 46,XY,der(13)t(12;13)(p12.1; p11).ish del(5)(p11p12); 46,XY, ish del(17)(p12p12); 46,XX.ish dup(11)(p13p13); and 46,X,idic(Y)(q11.2); and in two cases, mos 45,X/46XX. Autosomal abnormalities in three cases are likely to be pathogenic, and sex chromosome abnormalities in three follow previous findings. It is noteworthy that 10% of patients with schizophrenia have (sub)microscopic chromosomal abnormalities, indicating that genome-wide copy number survey should be considered in genetic studies of schizophrenia.
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Registered trials
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