ArticleProceedings of the National Academy of Sciences of the United States of America2008
T current potentiation increases the occurrence and temporal fidelity of synaptically evoked burst firing in sensory thalamic neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Orexinergic regulation of GABAergic input onto pyramidal neurons in the anterior cingulate cortex.Biophysical journal · 2025Article
- Developmentally Regulated Rebound Depolarization Enhances Spike Timing Precision in Auditory Midbrain Neurons.Frontiers in cellular neuroscience · 2020Article
- The Augmentation of Retinogeniculate Communication during Thalamic Burst Mode.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Multiplexed Spike Coding and Adaptation in the Thalamus.Cell reports · 2017Article
- T-type calcium channels in synaptic plasticity.Channels (Austin, Tex.) · 2017Review
- Corticothalamic Synaptic Noise as a Mechanism for Selective Attention in Thalamic Neurons.Frontiers in neural circuits · 2015Article
- Thalamic neuron models encode stimulus information by burst-size modulation.Frontiers in computational neuroscience · 2015Article
- Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Role for T-type Ca2+ channels in sleep waves.Pflugers Archiv : European journal of physiology · 2014Review
- The many faces of T-type calcium channels.Pflugers Archiv : European journal of physiology · 2014Review
- T-type calcium channels promote predictive homeostasis of input-output relations in thalamocortical neurons of lateral geniculate nucleus.Frontiers in computational neuroscience · 2014Article
- T-type calcium channels consolidate tonic action potential output of thalamic neurons to neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice.Epilepsia · 2012Article
- Midline thalamic paraventricular nucleus neurons display diurnal variation in resting membrane potentials, conductances, and firing patterns in vitro.Journal of neurophysiology · 2012Article
- PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Direct Corticosteroid Modulation of GABAergic Neurons in the Anterior Hypothalamic Area of GAD65-eGFP Mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2011Article
- Minimal alterations in T-type calcium channel gating markedly modify physiological firing dynamics.The Journal of physiology · 2011Article
- Phase advancement and nucleus-specific timing of thalamocortical activity during slow cortical oscillation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- State-dependent firing determines intrinsic dendritic Ca2+ signaling in thalamocortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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3 authors.
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Abstract
A growing number of in vivo experiments shows that high frequency bursts of action potentials can be recorded in thalamocortical neurons of awake animals. The mechanism underlying these bursts, however, remains controversial, because they have been proposed to depend on T-type Ca(2+) channels that are inactivated at the depolarized membrane potentials usually associated with the awake state. Here, we show that the transient potentiation of the T current amplitude, which is induced by neuronal depolarization, drastically increases the probability of occurrence and the temporal precision of T-channel-dependent high frequency bursts. The data, therefore, provides the first biophysical mechanism that might account for the generation of these high frequency bursts of action potentials in the awake state. Remarkably, this regulation finely tunes the response of thalamocortical neurons to the corticofugal excitatory and intrathalamic inhibitory afferents but not to sensory inputs.
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