ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Electrophysiological and neuroanatomical evidence of sexual dimorphism in aortic baroreceptor and vagal afferents in rat.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
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- Sex-dependent locus coeruleus vulnerability in Alzheimer's disease: gut dysbiosis as a driver and probiotic intervention as rescue.Biology of sex differences · 2026Review
- Sub-threshold depolarization differentially regulated by multiple ion channels plays a key role in initiation of baroreflex afferent neurotransmission evidenced from baroreceptor terminals to its cell bodies.Frontiers of medicine · 2025Article
- Distribution and morphology of CGRP-IR axons in flat-mounts of whole male and female mouse atria.Autonomic neuroscience : basic & clinical · 2025Article
- Article
- Key challenges in exploring the rat as a preclinical neurostimulation model for aortic baroreflex modulation in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Piezo1 channel activation facilitates baroreflex afferent neurotransmission with subsequent blood pressure reduction in control and hypertension rats.Acta pharmacologica Sinica · 2024Article
- Natriuretic Peptides-New Targets for Neurocontrol of Blood Pressure via Baroreflex Afferent Pathway.International journal of molecular sciences · 2022Article
- Estrogen-dependent depressor response of melatonin via baroreflex afferent function and intensification of PKC-mediated NaActa pharmacologica Sinica · 2022Article
- Bradykinin-mediated estrogen-dependent depressor response by direct activation of female-specific distribution of myelinated Ah-type baroreceptor neurons in rats.CNS neuroscience & therapeutics · 2022Article
- Characterization of a cell bridge variant connecting the nodose and superior cervical ganglia in the mouse: Prevalence, anatomical features, and practical implications.The Journal of comparative neurology · 2021Article
- Laterality Influences Central Integration of Baroreceptor Afferent Input in Male and Female Sprague Dawley Rats.Frontiers in physiology · 2020Article
- Identification of Leptin Receptor-Expressing Cells in the Nodose Ganglion of Male Mice.Endocrinology · 2019Article
- A review on ultrasonic neuromodulation of the peripheral nervous system: enhanced or suppressed activities?Applied sciences (Basel, Switzerland) · 2019Article
- Spontaneous activities in baroreflex afferent pathway contribute dominant role in parasympathetic neurocontrol of blood pressure regulation.CNS neuroscience & therapeutics · 2018Article
- Modeling the differentiation of A- and C-type baroreceptor firing patterns.Journal of computational neuroscience · 2017Article
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- Neuropeptide Y-mediated sex- and afferent-specific neurotransmissions contribute to sexual dimorphism of baroreflex afferent function.Oncotarget · 2016Article
- Article
- An afferent explanation for sexual dimorphism in the aortic baroreflex of rat.American journal of physiology. Heart and circulatory physiology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Evidence for sexual dimorphism in autonomic control of cardiovascular function is both compelling and confounding. Across healthy and disease populations sex-associated differences in neurocirculatory hemodynamics are far too complex to be entirely related to sex hormones. As an initial step toward identifying additional physiological mechanisms, we investigated whether there is a sex bias in the relative expression of low-threshold-myelinated and high-threshold-unmyelinated aortic baroreceptor afferents in rats. These two types of afferent fibers have markedly different reflexogenic effects upon heart rate and blood pressure and thus the potential impact upon baroreflex dynamics could be substantial. Our results, using a combination of a patch-clamp study of fluorescently identified aortic baroreceptor neurons (ABN) and morphometric analysis of aortic baroreceptor nerve fibers, demonstrate that females exhibit a greater percentage of myelinated baroreceptor fibers (24.8% vs. 18.7% of total baroreceptor fiber population, P < 0.01) and express a functional subtype of myelinated ABN rarely found in age-matched males (11% vs. 2.3%, n = 107, P < 0.01). Interestingly, this neuronal phenotype is more prevalent in the general population of female vagal afferent neurons (17.7% vs. 3.8%, n = 169, P < 0.01), and ovariectomy does not alter its expression but does lessen neuronal excitability. These data suggest there are fundamental neuroanatomical and electrophysiological differences between aortic baroreceptor afferents of female and male rats. Possible explanations are presented as to how such a greater prevalence of low-threshold myelinated afferents could be a contributing factor to the altered baroreflex sensitivity and vagal tone of females compared with males.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.