ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Airway house dust extract exposures modify allergen-induced airway hypersensitivity responses by TLR4-dependent and independent pathways.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Bcl10 Regulates Lipopolysaccharide-Induced Pro-Fibrotic Signaling in Bronchial Fibroblasts from Severe Asthma Patients.Biomedicines · 2022Article
- New Insights on the Role of pentraxin-3 in Allergic Asthma.Frontiers in allergy · 2021Review
- Human lung and monocyte-derived macrophages differ with regard to the effects of βRespiratory research · 2017Article
- Pentraxin 3 deletion aggravates allergic inflammation through a TThe Journal of allergy and clinical immunology · 2017Article
- Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization.Journal of immunology research · 2017Article
- NF-kappaB Signaling in Chronic Inflammatory Airway Disease.Biomolecules · 2015Review
- Trif-dependent induction of Th17 immunity by lung dendritic cells.Mucosal immunology · 2015Article
- The role of dendritic cells and monocytes in the maintenance and loss of respiratory tolerance.Current allergy and asthma reports · 2015Review
- The microbiota, chemical symbiosis, and human disease.Journal of molecular biology · 2014Review
- The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens.Nature medicine · 2012Article
- Innate and adaptive immune responses in asthma.Nature medicine · 2012Review
- New ways to turn on NKT cells.The Journal of experimental medicine · 2011Review
- Invariant NKT cells are required for airway inflammation induced by environmental antigens.The Journal of experimental medicine · 2011Article
- Regulatory T cells contribute to allergen tolerance induced by daily airway immunostimulant exposures.American journal of respiratory cell and molecular biology · 2011Article
- Activation of pulmonary dendritic cells and Th2-type inflammatory responses on instillation of engineered, environmental diesel emission source or ambient air pollutant particles in vivo.Journal of innate immunity · 2011Article
- Animal models of virus-induced chronic airway disease.Immunology and allergy clinics of North America · 2010Review
- Molecular determinants of T cell epitope recognition to the common Timothy grass allergen.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Regulation of aeroallergen immunity by the innate immune system: laboratory evidence for a new paradigm.Journal of innate immunity · 2010Review
- Targeting allergen to FcgammaRI reveals a novel T(H)2 regulatory pathway linked to thymic stromal lymphopoietin receptor.The Journal of allergy and clinical immunology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
TLR ligands and other allergen-nonspecific immunostimulatory molecules are ubiquitous in ambient air and have profound modulatory activities in animal models of allergic asthma. However, several of these molecules have been shown to promote exaggerated Th2-biased airway hypersensitivity responses (AHRs), whereas others attenuate the asthmatic phenotype. Therefore, it has proven difficult to extrapolate experimental results with purified molecules toward a more general understanding of the allergen-nonspecific immunomodulatory influence of living environments on the natural history of allergic asthma. These investigations determined how regular and intermittent airway exposures to an unpurified, but sterile house dust extract standard (HDEst) affected the OVA-specific AHR and immune status of previously Th2-sensitized mice. Low-dose daily and high-dose intermittent HDEst exposures modulated ongoing AHRs considerably, reducing eosinophil recruitment and methacholine responsiveness, while increasing neutrophilic inflammation. However, only daily airway delivery of low-dose HDEst attenuated OVA-specific Th2 cytokine production and Th2-biased AHRs to allergen challenge 1 mo later. Finally, whereas LPS mimicked many of the immunomodulatory characteristics of HDEst in this murine asthma model, daily airway HDEst delivery was highly effective in attenuating the AHR of OVA/alum-sensitized TLR4-deficient mice. Taken together, these investigations provide direct evidence that living environments contain allergen-nonspecific immunostimulatory molecules that influence the airway hypersensitivity status of allergen-sensitized mice by TLR4-dependent and independent mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.