ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Membrane protein Crry maintains homeostasis of the complement system.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Atypical hemolytic uremic syndrome: genetically-based insights into pathogenesis through an analysis of the complement regulator CD46.Annals of blood · 2023Article
- Complement inhibitor Crry expression in mouse placenta is essential for maintaining normal blood pressure and fetal growth.PloS one · 2020Article
- C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice.Frontiers in immunology · 2020Article
- Timing and mechanism of conceptus demise in a complement regulatory membrane protein deficient mouse.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Complement activation, a threat to pregnancy.Seminars in immunopathology · 2018Review
- C5a/C5aR Pathway Plays a Vital Role in Brain Inflammatory Injury via Initiating Fgl-2 in Intracerebral Hemorrhage.Molecular neurobiology · 2017Article
- Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.Kidney international · 2016Article
- Tissue-specific deletion of Crry from mouse proximal tubular epithelial cells increases susceptibility to renal ischemia-reperfusion injury.Kidney international · 2014Article
- Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Cell surface complement regulators moderate experimental myasthenia gravis pathology.Muscle & nerve · 2013Article
- Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis.Journal of inflammation (London, England) · 2012Article
- C3-dependent mechanism of microglial priming relevant to multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Structures of the rat complement regulator CrrY.Acta crystallographica. Section F, Structural biology and crystallization communications · 2011Article
- Properdin homeostasis requires turnover of the alternative complement pathway.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Ectromelia virus inhibitor of complement enzymes protects intracellular mature virus and infected cells from mouse complement.Journal of virology · 2010Article
- Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations.Journal of the American Society of Nephrology : JASN · 2010Article
- Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour.Trends in parasitology · 2009Review
- Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis.Immunology · 2009Article
- Surviving mousepox infection requires the complement system.PLoS pathogens · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Complement activation is tightly regulated to avoid excessive inflammatory and immune responses. Crry(-/-) is an embryonic lethal phenotype secondary to the maternal complement alternative pathway (AP) attacking a placenta deficient in this inhibitor. In this study, we demonstrate that Crry(-/-) mice could be rescued on a partial as well as on a complete factor B (fB)- or C3-deficient maternal background. The C3 and fB protein concentrations in Crry(-/-)C3(+/-) and Crry(-/-)fB(+/-) mice were substantially reduced for gene dosage secondary to enhanced AP turnover. Based on these observations, a breeding strategy featuring reduced maternal AP-activating capacity rescued the lethal phenotype. It led to a novel, stable line of Crry SKO mice carrying normal alleles for C3 and fB. Crry SKO mice also had accelerated C3 and fB turnover and therefore reduced AP- activating potential. These instructive results represent an example of a membrane regulatory protein being responsible for homeostasis of the complement system. They imply that there is constant turnover on cells of the AP pathway which functions as an immune surveillance system for pathogens and altered self.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.