ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Lymphocyte electrotaxis in vitro and in vivo.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02623660 (Accelerated Reduction of Post-operative Edema and Early Return to Function Following Total Knee Arthroplasty), which is not on this map. Cited by 70 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Accelerated Reduction of Post-operative Edema and Early Return to Function Following Total Knee Arthroplasty (TKA)
Who cites it
70 citing papers in PubMed.
- Cardio-microcurrent device for chronic heart failure: first-in-human clinical study.ESC heart failure · 2021Trial
- SCHEPHERD: A modular, programmable, direct current platform to control cell behavior.Science advances · 2026Article
- Modifiable PEDOT:PSS-based flexible diagnostic and therapeutic dressings for personalized wound management.Microsystems & nanoengineering · 2026Article
- Differential migratory phenotypes of human neutrophils and breast cancer cells in a wireless unidirectional electric field platform.Microsystems & nanoengineering · 2026Article
- Development of a Novel Immunoprotective Culture System for Parathyroid Allografts: Utilizing Static Magnetic Fields to Modulate Lymphocyte Migration.Current issues in molecular biology · 2026Article
- Hydrogel-Flexible Electronics Integrated Platforms for Diabetic Wound Management.Materials (Basel, Switzerland) · 2026Review
- Advances in electroactive materials-based strategies for promoting skin wound healing.Frontiers in medical technology · 2026Review
- The electrical tumor microenvironment: abnormalities and opportunities.Frontiers in oncology · 2026Review
- SCHEPHERD: A universal platform for high-throughput, high-resolution, and programmable control of cell behavior through bioelectric stimulation.bioRxiv : the preprint server for biology · 2025Article
- Advancing Chronic Wound Healing through Electrical Stimulation and Adipose-Derived Stem Cells.Advanced healthcare materials · 2025Review
- Spatiotemporal feature learning for actin dynamics.PloS one · 2025Article
- The Electric Field Guided HaCaT Cell Migration Through the EGFR/p38 MAPK/Akt Pathway.Current issues in molecular biology · 2024Article
- Review
- Direct Current Electrical Stimulation Shifts THP-1-Derived Macrophage Polarization towards Pro-Regenerative M2 Phenotype.International journal of molecular sciences · 2024Article
- Advances in electroactive biomaterials: Through the lens of electrical stimulation promoting bone regeneration strategy.Journal of orthopaedic translation · 2024Review
- Migration of human T cells can be differentially directed by electric fields depending on the extracellular microenvironment.iScience · 2024Article
- Electrical Stimulation for Immunomodulation.ACS omega · 2024Review
- Electrotaxis of Dictyostelium discoideum, Migration in an Electric Field.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A Workflow to Produce a Low-Cost In Vitro Platform for the Electric-Field Pacing of Cellularised 3D Porous Scaffolds.ACS biomaterials science & engineering · 2023Article
- Electric field-guided collective motility initiation of large epidermal cell groups.Molecular biology of the cell · 2023Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Electric fields are generated in vivo in a variety of physiologic and pathologic settings, including penetrating injury to epithelial barriers. An applied electric field with strength within the physiologic range can induce directional cell migration (i.e., electrotaxis) of epithelial cells, endothelial cells, fibroblasts, and neutrophils suggesting a potential role in cell positioning during wound healing. In the present study, we investigated the ability of lymphocytes to respond to applied direct current (DC) electric fields. Using a modified Transwell assay and a simple microfluidic device, we show that human PBLs migrate toward the cathode in physiologically relevant DC electric fields. Additionally, electrical stimulation activates intracellular kinase signaling pathways shared with chemotactic stimuli. Finally, video microscopic tracing of GFP-tagged immunocytes in the skin of mouse ears reveals that motile cutaneous T cells actively migrate toward the cathode of an applied DC electric field. Lymphocyte positioning within tissues can thus be manipulated by externally applied electric fields, and may be influenced by endogenous electrical potential gradients as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.