ArticleJournal of neurophysiology2008
Function of neuromuscular synapses in the zebrafish choline-acetyltransferase mutant bajan.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Distinct transcriptional programs define cranial motor neuron subtypes during vertebrate development.bioRxiv : the preprint server for biology · 2026Article
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- A multilevel screening pipeline in zebrafish identifies therapeutic drugs for GAN.EMBO molecular medicine · 2023Article
- Presynaptic Congenital Myasthenic Syndromes: Understanding Clinical Phenotypes through In vivo Models.Journal of neuromuscular diseases · 2023Review
- Neuro- and Cardiovascular Activities ofBiology · 2022Article
- Neuropathy-associated histidyl-tRNA synthetase variants attenuate protein synthesis in vitro and disrupt axon outgrowth in developing zebrafish.The FEBS journal · 2021Article
- Zebrafish neuromuscular junction: The power of N.Neuroscience letters · 2019Review
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- Fatigue in Rapsyn-Deficient Zebrafish Reflects Defective Transmitter Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- ALS-linked protein disulfide isomerase variants cause motor dysfunction.The EMBO journal · 2016Article
- Defects of the Glycinergic Synapse in Zebrafish.Frontiers in molecular neuroscience · 2016Review
- Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease.Disease models & mechanisms · 2012Article
- Behavioral genetics in larval zebrafish: learning from the young.Developmental neurobiology · 2012Review
- Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Paired patch clamp recordings from motor-neuron and target skeletal muscle in zebrafish.Journal of visualized experiments : JoVE · 2010Article
- Distinct retinal deficits in a zebrafish pyruvate dehydrogenase-deficient mutant.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Analysis of a zebrafish behavioral mutant reveals a dominant mutation in atp2a1/SERCA1.Genesis (New York, N.Y. : 2000) · 2010Article
- Defective glycinergic synaptic transmission in zebrafish motility mutants.Frontiers in molecular neuroscience · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We have identified a zebrafish mutant line, bajan, in which compromised motility and fatigue result from a point mutation in the gene coding choline acetyltransferase (ChAT), the enzyme responsible for acetylcholine (ACh) synthesis. Although the mutation predicts loss of ChAT function, bajan inexplicably retains low levels of neuromuscular transmission. We exploited this residual activity and determined the consequences for synaptic function. The attenuated synaptic responses were a direct consequence of a decrease in both resting mean quantal size and quantal content. To replicate behavioral fatigue in swimming, motorneurons were stimulated at high frequencies. A prominent reduction in quantal content, reflecting vesicle depletion, was coincident with a small additional reduction in quantal size. In humans, defective ChAT leads to episodic apnea, a form of congenital myasthenic syndrome characterized by use-dependent fatigue. In contrast to bajan, however, afflicted individuals exhibit a normal resting quantal size and quantal content. The fatigue in humans results from a pronounced long-lasting drop in quantal size with little or no change in quantal content. These differences have important implications for interpreting fatigue as well as on understanding the impact of ACh availability on vesicle filling and recycling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.