ArticleJournal of neurophysiology2008
Mitochondrial calcium buffering contributes to the maintenance of Basal calcium levels in mouse taste cells.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Nutrient Sensing by Lingual G-Protein-Coupled Taste Receptors.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Defining the role of TRPM4 in broadly responsive taste receptor cells.Frontiers in cellular neuroscience · 2023Article
- Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation.Frontiers in human neuroscience · 2021Review
- An alternative pathway for sweet sensation: possible mechanisms and physiological relevance.Pflugers Archiv : European journal of physiology · 2020Review
- 12(S)-HETE mediates diabetes-induced endothelial dysfunction by activating intracellular endothelial cell TRPV1.The Journal of clinical investigation · 2020Article
- A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli.PLoS genetics · 2020Article
- Sensing Senses: Optical Biosensors to Study Gustation.Sensors (Basel, Switzerland) · 2020Review
- Differential Effects of Diet and Weight on Taste Responses in Diet-Induced Obese Mice.Obesity (Silver Spring, Md.) · 2020Article
- The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells.Life science alliance · 2019Article
- The thiosemicarbazone MeCell death & disease · 2018Article
- AP1 transcription factors are required to maintain the peripheral taste system.Cell death & disease · 2016Article
- Calcium signaling in taste cells.Biochimica et biophysica acta · 2015Review
- Denatonium inhibits growth and induces apoptosis of airway epithelial cells through mitochondrial signaling pathways.Respiratory research · 2015Article
- Knocking out P2X receptors reduces transmitter secretion in taste buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Expression of calcium binding proteins in mouse type II taste cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Sarco/Endoplasmic reticulum Ca2+-ATPases (SERCA) contribute to GPCR-mediated taste perception.PloS one · 2011Article
- Acid stimulation (sour taste) elicits GABA and serotonin release from mouse taste cells.PloS one · 2011Article
- Calcium signaling in taste cells: regulation required.Chemical senses · 2010Review
- Intracellular Ca(2+) and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells.The Journal of physiology · 2010Article
- Sodium/calcium exchangers selectively regulate calcium signaling in mouse taste receptor cells.Journal of neurophysiology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Taste stimuli are detected by taste receptor cells present in the oral cavity using diverse signaling pathways. Some taste stimuli are detected by G protein-coupled receptors (GPCRs) that cause calcium release from intracellular stores, whereas other stimuli depolarize taste cells to cause calcium influx through voltage-gated calcium channels (VGCCs). Although taste cells use two distinct mechanisms to transmit taste signals, increases in cytosolic calcium are critical for normal responses in both pathways. This creates a need to tightly control intracellular calcium levels in all transducing taste cells. To date, however, the mechanisms used by taste cells to regulate cytosolic calcium levels have not been identified. Studies in other cell types have shown that mitochondria can be important calcium buffers, even during small changes in calcium loads. In this study, we used calcium imaging to characterize the role of mitochondria in buffering calcium levels in taste cells. We discovered that mitochondria make important contributions to the maintenance of resting calcium levels in taste cells by routinely buffering a constitutive calcium influx across the plasma membrane. This is unusual because in other cell types, mitochondrial calcium buffering primarily affects large evoked calcium responses. We also found that the amount of calcium that is buffered by mitochondria varies with the signaling pathways used by the taste cells. A transient receptor potential (TRP) channel, likely TRPV1 or a taste variant of TRPV1, contributes to the constitutive calcium influx.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.