ArticleInternational journal of epidemiology2009
A fingerprint marker from early gestation associated with diabetes in middle age: the Dutch Hunger Winter Families Study.
Article in International journal of epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Assessment of Environmental and Hereditary Influence on Development of Pituitary Tumors Using Dermatoglyphic Traits and Their Potential as Screening Markers.International journal of environmental research and public health · 2016Trial
- Dermatoglyphics as a Risk Indicator for Anterior Cruciate Ligament Injuries in Futsal Athletes.Journal of functional morphology and kinesiology · 2025Article
- Circadian Disruption across Lifespan Impairs Glucose Homeostasis and Insulin Sensitivity in Adult Mice.Metabolites · 2024Article
- The regulation of endocrine-disrupting chemicals to minimize their impact on health.Nature reviews. Endocrinology · 2023Review
- Association of famine exposure and the serum calcium level in healthy Chinese adults.Frontiers in endocrinology · 2022Article
- Association between gestational period and obesity in children with the use of dermatoglyphic traits: A preliminary study.PloS one · 2021Article
- Qualitative and quantitative dermatoglyphics of chronic kidney disease of unknown origin (CKDu) in Sri Lanka.Journal of physiological anthropology · 2020Article
- Birth weight and type 2 diabetes: A meta-analysis.Experimental and therapeutic medicine · 2017Article
- A New Method to Assess Asymmetry in Fingerprints Could Be Used as an Early Indicator of Type 2 Diabetes Mellitus.Journal of diabetes science and technology · 2016Article
- Longitudinal analysis of DNA methylation associated with birth weight and gestational age.Human molecular genetics · 2015Article
- Dermatoglyphic meta-analysis indicates early epigenetic outcomes & possible implications on genomic zygosity in type-2 diabetes.F1000Research · 2015Article
- Quantification of excess risk for diabetes for those born in times of hunger, in an entire population of a nation, across a century.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- DNA methylation program during development.Frontiers in biology · 2012Article
- Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome?Nutrition reviews · 2012Review
- Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role.Advances in nutrition (Bethesda, Md.) · 2012Review
- Prenatal famine and adult health.Annual review of public health · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFetal programming of diabetes might originate in early pregnancy when fingerprints are permanently established. The mean dermatoglyphic ridge count difference between fingertips 1 and 5 ('Md15') varies with the early prenatal environment. We hypothesized that Md15 would be associated with adult-onset diabetes.
methodsWe obtained Md15 from 577 Dutch adults (aged 58.9 years, SD 1.1) whose births in 1943-47 were documented in maternity records and from 260 of their same-sex siblings for whom birth weights were not available. Of these 837 participants, complete anthropometry and diabetes status (from history or glucose tolerance test) were obtained for 819.
resultsAfter adjustment for age, sex, parental diabetes and adult anthropometry, fingerprint Md15 was associated with prevalent diabetes [odds ratio (OR) = 1.37 per 1 SD (95% confidence interval 1.02-1.84)]. This relationship held [OR = 1.40 (1.03-1.92)] for diabetic cases restricted to those recently diagnosed (within 7 years). In the birth series restricted to recently diagnosed cases, the mutually adjusted ORs were 1.34 (1.00-1.79) per SD of Md15 and 0.83 (0.62-1.10) per SD of birth weight. Further adjustments for maternal smoking, conception season or prenatal famine exposure in 1944-45 did not alter these estimates. Among 42 sibling pairs discordant for diabetes, the diabetic sibling had higher Md15 by 3.5 (0.6-6.3) after multivariable adjustment.
conclusionsDiabetes diagnosed at age 50+ years was associated with a fingerprint marker established in early gestation, irrespective of birth weight. Fingerprints may provide a useful tool to investigate prenatal developmental plasticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.