ArticleAnnals of the rheumatic diseases2009
Non-inherited maternal human leukocyte antigen alleles in susceptibility to familial rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Donor HLA-DR Drives the Development of De Novo Autoimmunity Following Lung and Heart Transplantation.Transplantation direct · 2020Article
- Review
- Human Leukocyte Antigen-Disease Associations in Rheumatoid Arthritis.Rheumatic diseases clinics of North America · 2017Review
- Rheumatoid arthritis: Forward and reverse inheritance - the yin and the yang.Nature reviews. Rheumatology · 2017Article
- Association of MASP-2 levels and MASP2 gene polymorphisms with rheumatoid arthritis in patients and their relatives.PloS one · 2014Article
- Article
- The otherness of self: microchimerism in health and disease.Trends in immunology · 2012Review
- Acquisition of the rheumatoid arthritis HLA shared epitope through microchimerism.Arthritis and rheumatism · 2011Article
- Parity and HLA alleles in risk of rheumatoid arthritis.Chimerism · 2011Article
- Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host?Blood · 2010Article
- Interstitial lung diseases in children.Orphanet journal of rare diseases · 2010Review
- Analysis of maternal-offspring HLA compatibility, parent-of-origin effects, and noninherited maternal antigen effects for HLA-DRB1 in systemic lupus erythematosus.Arthritis and rheumatism · 2010Article
- The rheumatoid arthritis HLA-DRB1 shared epitope.Current opinion in rheumatology · 2010Review
- Why are women predisposed to autoimmune rheumatic diseases?Arthritis research & therapy · 2009Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesSome patients with rheumatoid arthritis (RA) lack RA-associated human leukocyte antigen (HLA) alleles. Prior studies investigated non-inherited maternal HLA alleles (NIMA) in RA risk with conflicting results.
methodsWe examined NIMA in a large cohort of families from the North American Rheumatoid Arthritis Consortium (NARAC).
resultsAmong 620 patients with 1 or both parents having a HLA genotype, patients with RA informative for analysis included 176 without HLA-DRB1*04 and 86 without the HLA shared epitope (SE). The frequency of NIMA encoding HLA-DR4 or the SE was compared to the non-inherited paternal allele (NIPA). DR4-encoding NIMA vs NIPA revealed no significant difference (27% vs 20%). However, parity is known to modulate RA risk and analyses stratified by sex and age of onset showed significant variation among women. Interestingly, among women with onset <45 years DR4-encoding NIMA was increased compared to NIPA; among women > or =45 years at onset the reverse was observed (31% vs 16% compared to 10% vs 60%, p = 0.008). DR4 encoding NIMA vs NIPA did not differ in men. The SE did not differ in men or women.
conclusionsRisk of RA was associated with HLA-DR4 encoding NIMA in younger-onset women but not in older-onset women or men. These observations could help explain conflicting prior results of NIMA in RA.
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