ReviewProceedings of the American Thoracic Society2008
Mesenchymal stem cells as vectors for lung disease.
Review in Proceedings of the American Thoracic Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- The effects of IL-1β stimulated human umbilical cord mesenchymal stem cells on polarization and apoptosis of macrophages in rheumatoid arthritis.Scientific reports · 2023Article
- Advances in mesenchymal stem cell-mediated tissue repair of lung injury.Chronic diseases and translational medicine · 2021Article
- Interleukin-1Stem cells international · 2019Article
- Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model.Journal of experimental & clinical cancer research : CR · 2015Article
- Mechanisms of cellular therapy in respiratory diseases.Intensive care medicine · 2011Review
- Stem cells and cell therapies in lung biology and lung diseases.Proceedings of the American Thoracic Society · 2011Article
- Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- Transplantation of adipose derived stromal cells into the developing mouse eye.Acta histochemica et cytochemica · 2010Article
- Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- TRAIL-expressing mesenchymal stem cells kill the putative cancer stem cell population.British journal of cancer · 2010Article
- Mesenchymal stem cells modulate lung injury.Proceedings of the American Thoracic Society · 2010Review
- Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles.Cancer research · 2009Article
- Developing cell therapy techniques for respiratory disease: intratracheal delivery of genetically engineered stem cells in a murine model of airway injury.Human gene therapy · 2009Article
- Importin 13 serves as a potential marker for corneal epithelial progenitor cells.Stem cells (Dayton, Ohio) · 2009Article
- Identification of functional progenitor cells in the pulmonary vasculature.Pulmonary circulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Stem cells divide asymmetrically, leading to self-renewal and the production of a daughter cell committed to differentiation. This property has engendered excitement as to the use of these cells for treatments. The majority of the work with stem cells has used the relatively accessible and well-characterized adult bone marrow stem cell compartment. Initially the focus of this research was on the potential for these stem cells to repair damaged organs by differentiating into epithelial cells to replace the injured areas. More recently it has become clear that engraftment of these stem cells as epithelial tissue is a rare event with perhaps limited clinical significance. Despite this, stem cells appear to have the ability to home to and be specifically recruited to areas of inflammation and injured tissues often characterized by excessive extracellular matrix deposition. As a consequence they are intimately involved in regions of physiological and pathological repair. Coupled with this, autologous hematopoietic stem cells, or the relatively immunoprivileged mesenchymal stem cells, can be expanded and engineered ex vivo and reintroduced without immunomodulation. The prospect of using such cells clinically as a cellular therapy holds much promise for many conditions and organ pathologies. Here we address the evidence for the incorporation of bone marrow stem cells into areas of stroma formation as a prelude to possible future treatment options for common lung diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.