ArticleGynecologic oncology2008
What women with ovarian cancer think and know about genetic testing.
Article in Gynecologic oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00486707 (Questionnaire for Ovarian Cancer Patients Regarding Acceptance and Willingness to Undergo Genetic Testing), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Questionnaire for Ovarian Cancer Patients Regarding Acceptance and Willingness to Undergo Genetic Testing
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Awareness, knowledge, perceptions, and attitudes towards genetic testing for cancer risk among ethnic minority groups: a systematic review.BMC public health · 2017Pooled it
- Obstacles in genetic testing for germline BRCA1/2 pathogenic mutations in patients with primary breast and ovarian cancer in Switzerland.Archives of gynecology and obstetrics · 2025Article
- Article
- Understanding the Information Needs of Patients With Ovarian Cancer Regarding Genetic Testing to Inform Intervention Design: Interview Study.JMIR cancer · 2022Article
- Recall of Genomic Testing Results Among Patients with Cancer.The oncologist · 2021Article
- Low rates of cascade genetic testing among families with hereditary gynecologic cancer: An opportunity to improve cancer prevention.Gynecologic oncology · 2020Article
- Article
- Cancer Genetic Counseling and Testing: Perspectives of Epithelial Ovarian Cancer Patients and Gynecologic Oncology Healthcare Providers.Journal of genetic counseling · 2018Article
- Article
- The effect of a celebrity health disclosure on demand for health care: trends in BRCA testing and subsequent health services use.Journal of community genetics · 2017Article
- Genetics Consultation Rates Following a Diagnosis of High-Grade Serous Ovarian Carcinoma in the Canadian Province of Ontario.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2017Article
- Video-assisted genetic counseling in patients with ovarian, fallopian and peritoneal carcinoma.Gynecologic oncology · 2016Article
- Does a medical history of hypertension influence disclosing genetic testing results of the risk for salt-sensitive hypertension, in primary care?International journal of general medicine · 2016Article
- Acceptance of, inclination for, and barriers in genetic testing for gene mutations that increase the risk of breast and ovarian cancers among female residents of Warsaw.Contemporary oncology (Poznan, Poland) · 2016Article
- Adherence patterns to National Comprehensive Cancer Network (NCCN) guidelines for referral to cancer genetic professionals.Gynecologic oncology · 2015Article
- Concerns about cancer risk and experiences with genetic testing in a diverse population of patients with breast cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Article
- Development of an integrated support system for hereditary cancer and its impact on gynecologic services.International journal of clinical oncology · 2014Article
- Underestimation of risk of a BRCA1 or BRCA2 mutation in women with high-grade serous ovarian cancer by BRCAPRO: a multi-institution study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Article
- Bumps along the translational pathway: anticipating uptake of tailored smoking cessation treatment.Personalized medicine · 2013Article
- Genetic risk assessment for women with epithelial ovarian cancer: referral patterns and outcomes in a university gynecologic oncology clinic.Journal of genetic counseling · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesFew women with ovarian cancer undergo genetic testing for the Breast and Ovarian Cancer susceptibility genes, BRCA1 and BRCA2. With the prospect of BRCA-directed therapeutics, we investigated ovarian cancer patients' knowledge and willingness to undergo genetic testing.
methodsAll ovarian cancer patients seen in the Gynecology Center of a cancer center and a private clinic were asked to complete an anonymous questionnaire regarding knowledge and willingness to undergo BRCA testing. Women who had prior genetic testing were asked not to participate. Data was analyzed using Fisher's exact test.
resultsTwo-hundred and thirty seven ovarian cancer patients voluntarily completed the questionnaire. Fifty-five percent (131/237) of participants had not heard of BRCA testing. Of Caucasian respondents, 51% were unaware of BRCA testing, compared to 70% of Hispanic and 88% of African American respondents (p=0.008). Awareness was correlated with education (p<0.001). Eighty-nine percent of participants were willing to be tested if it would directly affect their therapy and 86.9% would be tested to benefit their family. Seventy-four percent of patients would pay 20% of the cost of testing, only 25.1% would pay in full.
conclusionsA majority of women with ovarian cancer are not aware of the availability of BRCA testing. This lack of awareness is more profound in minorities. Despite lack of knowledge, most patients would undergo testing if it would impact their care. However, cost may be a barrier. Given the willingness of patients to undergo testing and the possibility of targeted therapy, clinicians who care for these patients should work to make appropriate genetic counseling referrals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.