Evidence map›Paper›PMID 18683014›Full record

Trial reportObesity surgery2009

Changes in bone mineral density, body composition and adiponectin levels in morbidly obese patients after bariatric surgery.

Fernando Carrasco, Manuel Ruz, Pamela Rojas, Attila Csendes, Annabella Rebolledo, Juana Codoceo, Jorge Inostroza, Karen Basfi-Fer, Karin Papapietro, Jorge Rojas and 2 more

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02811393 (Assessment of the Muscle Function Test in Women Who Have Undergone Roux-en-Y Gastric Bypass Surgery), which is not on this map. Cited by 79 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02811393 completednot on this mapstarted 2016, after this paper: background citation

Assessment of the Muscle Function Test in Women Who Have Undergone Roux-en-Y Gastric Bypass Surgery

TypeobservationalSponsorUniversity of ChileRan2016 to 2019Enrolled26ConditionsMuscle Function, Handgrip Strength TestArmsAssess muscle function
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 170 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015
    Trial
  9. Trial
  10. Two-year changes in bone density after Roux-en-Y gastric bypass surgery.The Journal of clinical endocrinology and metabolism · 2015
    Trial
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Review
  18. Secondary Osteoporosis and Metabolic Bone Diseases.Journal of clinical medicine · 2022
    Review
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Fernando CarrascoDepartment of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Postal Code 838-0453, Santiago, Chile. fcarrasc@med.uchile.cl
Manuel Ruz
Pamela Rojas
Attila Csendes
Annabella Rebolledo
Juana Codoceo
Jorge Inostroza
Karen Basfi-Fer
Karin Papapietro
Jorge Rojas
Fernando Pizarro
Manuel Olivares
University of Chile · CLHospital Clínico de la Universidad de Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric bypass surgery (GBP) is increasingly used as a treatment option in morbid obesity. Little is known about the effects of this surgery on bone mineral density (BMD) and the underlying mechanisms. To evaluate changes on BMD after GBP and its relation with changes in body composition and serum adiponectin, a longitudinal study in morbid obese subjects was conducted.

methodsForty-two women (BMI 45.0 +/- 4.3 kg/m(2); 37.7 +/- 9.6 years) were studied before surgery and 6 and 12 months after GBP. Percentage of body fat (%BF), fat-free mass (FFM), and BMD were measured by dual-energy X-ray absorptiometry and serum adiponectin levels by RIA.

resultsTwelve months after, GBP weight was decreased by 34.4 +/- 6.5% and excess weight loss was 68.2 +/- 12.8%. Significant reduction (p < 0.001) in total BMD (-3.0 +/- 2.1%), spine BMD (-7.4 +/- 6.8%) and hip BMD (-10.5 +/- 5.6%) were observed. Adiponectin concentration increased from 11.4 +/- 0.7 mg/L before surgery to 15.7 +/- 0.7 and 19.8 +/- 1.0 at the sixth and twelfth month after GBP, respectively (p < 0.001). Thirty-seven percent of the variation in total BMD could be explained by baseline weight, initial BMD, BF reduction, and adiponectin at the twelfth month (r (2) = 0.373; p < 0.001). Adiponectin at the twelfth month had a significant and positive correlation with the reduction of BMD, unrelated to baseline and variation in body composition parameters (adjusted correlation coefficient: r = 0.36).

conclusionGBP induces a significant BMD loss related with changes in body composition, although some metabolic mediators, such as adiponectin increase, may have an independent action on BMD which deserves further study.

Indexed as

Body CompositionBone DensityGastric BypassAdiponectinAdultBody Mass IndexDietFemaleFollow-Up StudiesHumansMiddle AgedObesity, MorbidProspective StudiesWeight LossYoung AdultAdiponectin

Identifiers

PMID18683014
OpenAlexW2091509467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.