ArticleMolecular and cellular biochemistry2009
Role of MAPK in mechanical force-induced up-regulation of type I collagen and osteopontin in human gingival fibroblasts.
Article in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Hyperbaric Oxygen Therapy to Minimize Orthodontic Relapse in Rabbits.European journal of dentistry · 2024Article
- Advances in the molecular pathogenesis and cell therapy of stress urinary incontinence.Frontiers in cell and developmental biology · 2023Review
- Mechanical force promotes the proliferation and extracellular matrix synthesis of human gingival fibroblasts cultured on 3D PLGA scaffolds via TGF‑β expression.Molecular medicine reports · 2019Article
- Periodontal cell mechanotransduction.Open biology · 2018Review
- Role of osteopontin in bone remodeling and orthodontic tooth movement: a review.Progress in orthodontics · 2018Review
- Does Oxidative Stress Induced by Alcohol Consumption Affect Orthodontic Treatment Outcome?Frontiers in physiology · 2017Review
- Isolation and characterisation of human gingival margin-derived STRO-1/MACS(+) and MACS(-) cell populations.International journal of oral science · 2015Article
- [Effects of hirudin on the expression of basic fibroblast growth factor and transforming growth factor-β1 in human gingival fibroblasts].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2015Article
- Dynamic reciprocity between cells and their microenvironment in reproduction.Biology of reproduction · 2015Review
- Article
- The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts.The Journal of biological chemistry · 2014Article
- Combating Adaptation to Cyclic Stretching By Prolonging Activation of Extracellular Signal-Regulated Kinase.Cellular and molecular bioengineering · 2013Article
- Fibroblast growth factor-4 enhances proliferation of mouse embryonic stem cells via activation of c-Jun signaling.PloS one · 2013Article
- Gene analysis of signal transduction factors and transcription factors in periodontal ligament cells following application of dynamic strain.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2012Article
- Mechanosensitive mechanisms in transcriptional regulation.Journal of cell science · 2012Review
- Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts.Molecular and cellular biochemistry · 2010Article
- Matrix metalloproteinase 2 activity decreases in human periodontal ligament fibroblast cultures submitted to simulated orthodontic force.In vitro cellular & developmental biology. Animal · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to periodontal ligament, the gingival plays an important role in alveolar bone remodeling induced by physiological and mechanical stimuli. However, there are few reports showing the cellular responses of human gingival fibroblasts (HGF) to a mechanical force. This study examined the effects of centrifugal force on the proliferation of the bone tissue components, such as type I collagen (COL I), osteopontin (OPN), and osteonectin (ONN) in the HGF. The roles of extracellular signal-regulated kinase (ERK), c-Jun-N-terminal kinase (JNK), and p-38 kinase were also investigated. Centrifugal force induced cell cycle arrest in the G(1) phase without any cytotoxic effects and increased the levels of COL I and OPN expression in the cells but had no effect on ONN. The force-induced up-regulation of COL I was found to be mediated by both the ERK-c-Fos-COL I and JNK-c-Jun-COL I pathways, while that of OPN was mediated only by the ERK-mediated pathway. Our present findings suggest that centrifugal force up-regulates COL I and OPN expression in HGF, where both ERK and JNK play indispensable roles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.