ArticlePloS one2008
Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine release.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 93 citations in OpenAlex.
- Individual differences in amygdala reactivity following nicotinic receptor stimulation in abstinent smokers.NeuroImage · 2013Trial
- Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration.Proceedings of the National Academy of Sciences of the United States of America · 2008Trial
- Disruption of positive- and negative-feature morphine interoceptive occasion setters by dopamine receptor agonism and antagonism in male and female rats.Psychopharmacology · 2024Article
- A large-scale c-Fos brain mapping study on extinction of cocaine-primed reinstatement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Cocaine hydrochloride, cocaine methiodide and methylenedioxypyrovalerone (MDPV) cause distinct alterations in the structure and composition of the gut microbiota.Scientific reports · 2023Article
- Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Prelimbic cortical projections to rostromedial tegmental nucleus play a suppressive role in cue-induced reinstatement of cocaine seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight.Pharmacological reviews · 2021Review
- Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- There's no place like home? Return to the home cage triggers dopamine release in the mouse nucleus accumbens.Neurochemistry international · 2021Article
- The Critical Role of Peripheral Targets in Triggering Rapid Neural Effects of Intravenous Cocaine.Neuroscience · 2020Review
- Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine.Nature communications · 2018Article
- The Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines.Frontiers in integrative neuroscience · 2018Article
- Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Rapid induction of dopamine sensitization in the nucleus accumbens shell induced by a single injection of cocaine.Behavioural brain research · 2017Article
- Bidirectional regulation over the development and expression of loss of control over cocaine intake by the anterior insula.Psychopharmacology · 2017Article
- Regional influence of cocaine on evoked dopamine release in the nucleus accumbens core: A role for the caudal brainstem.Brain research · 2017Article
- Reciprocal Inhibitory Interactions Between the Reward-Related Effects of Leptin and Cocaine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Gabapentin potentiates sensitivity to the interoceptive effects of alcohol and increases alcohol self-administration in rats.Neuropharmacology · 2016Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Intravenous injections of cocaine HCl are habit-forming because, among their many actions, they elevate extracellular dopamine levels in the terminal fields of the mesocorticolimbic dopamine system. This action, thought to be very important for cocaine's strong addiction liability, is believed to have very short latency and is assumed to reflect rapid brain entry and pharmacokinetics of the drug. However, while intravenous cocaine HCl has almost immediate effects on behavior and extracellular dopamine levels, recent evidence suggests that its central pharmacological effects are not evident until 10 or more seconds after IV injection. Thus the immediate effects of a given intravenous cocaine injection on extracellular dopamine concentration and behavior appear to occur before there is sufficient time for cocaine to act centrally as a dopamine uptake inhibitor. To explore the contribution of peripheral effects of cocaine to the early activation of the dopamine system, we used brain microdialysis to measure the effects of cocaine methiodide (MI)--a cocaine analogue that does not cross the blood brain barrier--on glutamate (excitatory) input to the dopamine cells. IP injections of cocaine MI were ineffective in cocaine-naïve animals but stimulated ventral tegmental glutamate release in rats previously trained to lever-press for cocaine HCl. This peripherally triggered glutamate input was sufficient to reinstate cocaine-seeking in previously trained animals that had undergone extinction of the habit. These findings offer an explanation for short-latency behavioral responses and immediate dopamine elevations seen following cocaine injections in cocaine-experienced but not cocaine-naïve animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.