ArticleBritish journal of cancer2008
Induction of sodium iodide symporter gene and molecular characterisation of HNF3 beta/FoxA2, TTF-1 and C/EBP beta in thyroid carcinoma cells.
Article in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- CEBPB emerges as a key regulatory factor in human cancers through diverse molecular mechanisms and clinical implications.Discover oncology · 2025Review
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- BI-847325, a selective dual MEK and Aurora kinases inhibitor, reduces aggressive behavior of anaplastic thyroid carcinoma on an in vitro three-dimensional culture.Cancer cell international · 2022Article
- Regulation of platelet-activating factor-induced interleukin-8 expression by protein tyrosine phosphatase 1B.Cell communication and signaling : CCS · 2019Article
- Hepatocyte Nuclear Factor 3β Plays a Suppressive Role in Colorectal Cancer Progression.Frontiers in oncology · 2019Article
- Article
- Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo.Oncotarget · 2017Article
- Novel genetic variants in differentiated thyroid cancer and assessment of the cumulative risk.Scientific reports · 2015Article
- Vitamin D and thyroid disease: to D or not to D?European journal of clinical nutrition · 2015Review
- The transcription factor FOXA2 suppresses gastric tumorigenesis in vitro and in vivo.Digestive diseases and sciences · 2015Article
- Histone post-translational modifications induced by histone deacetylase inhibition in transcriptional control units of NIS gene.Molecular biology reports · 2014Article
- Functional analysis of three novel cell lines derived from human papillary thyroid carcinomas with three different clinical courses.Human cell · 2014Article
- Inhibiting proliferation of gefitinib-resistant, non-small cell lung cancer.Cancer chemotherapy and pharmacology · 2013Article
- 5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro.Thyroid : official journal of the American Thyroid Association · 2013Article
- The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- C5a-regulated CCAAT/enhancer-binding proteins β and δ are essential in Fcγ receptor-mediated inflammatory cytokine and chemokine production in macrophages.The Journal of biological chemistry · 2012Article
- CCAAT/enhancer-binding protein γ is a critical regulator of IL-1β-induced IL-6 production in alveolar epithelial cells.PloS one · 2012Article
- Recent advances in molecular diagnosis of thyroid cancer.Journal of thyroid research · 2011Article
- Microarray analysis of papillary thyroid cancers in Korean.The Korean journal of internal medicine · 2010Article
- Sodium iodide symporter and the radioiodine treatment of thyroid carcinoma.Nuclear medicine and molecular imaging · 2010Review
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid carcinoma cells often do not express thyroid-specific genes including sodium iodide symporter (NIS), thyroperoxidase (TPO), thyroglobulin (TG), and thyrotropin-stimulating hormone receptor (TSHR). Treatment of thyroid carcinoma cells (four papillary and two anaplastic cell lines) with histone deacetylase inhibitors (SAHA or VPA) modestly induced the expression of the NIS gene. The promoter regions of the thyroid-specific genes contained binding sites for hepatocyte nuclear factor 3 beta (HNF3 beta)/forkhead box A2 (FoxA2), thyroid transcription factor 1 (TTF-1), and CCAAT/enhancer binding protein (C/EBP beta). Quantitative reverse transcription-polymerase chain reaction (RT-PCR) showed decreased expression of HNF3 beta/FoxA2 and TTF-1 mRNA in papillary thyroid carcinoma cell lines, when compared with normal thyroid cells. Forced expression of these genes in papillary thyroid carcinoma cells inhibited their growth. Furthermore, the CpG island in the promoter region of HNF3 beta/FoxA2 was aberrantly methylated; and treatment with 5-aza-2-deoxycytidine (5-Az) induced its expression. Immunohistochemical staining showed that C/EBP beta was localised in the nucleus in normal thyroid cells but was detected in the cytoplasm in papillary thyroid carcinoma cells. Subcellular fractionation of papillary thyroid carcinoma cell lines also demonstrated high levels of expression of C/EBP beta in the cytoplasm, suggesting that a large proportion of C/EBP beta protein is inappropriately localised in the cytoplasm. In summary, these findings reveal novel abnormalities in thyroid carcinoma cells.
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