ArticleMolecular systems biology2008
Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response.
Article in Molecular systems biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Proteomic identification of potential target proteins regulated by the SCF(F) (bp1) -mediated proteolysis pathway in Fusarium oxysporum.Molecular plant pathology · 2013Article
- Multiple MAPK cascades regulate the transcription of IME1, the master transcriptional activator of meiosis in Saccharomyces cerevisiae.PloS one · 2013Article
- Positive roles for negative regulators in the mating response of yeast.Molecular systems biology · 2012Article
- A novel family of dehydrin-like proteins is involved in stress response in the human fungal pathogen Aspergillus fumigatus.Molecular biology of the cell · 2011Article
- Design principles and specificity in biological networks with cross activation.Physical biology · 2011Article
- The homeodomain transcription factor Ste12: Connecting fungal MAPK signalling to plant pathogenicity.Communicative & integrative biology · 2010Article
- Mechanisms and constraints on yeast MAPK signaling specificity.Biophysical journal · 2009Article
- Efficient yeast ChIP-Seq using multiplex short-read DNA sequencing.BMC genomics · 2009Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
The yeast transcription factor Ste12 controls both mating and filamentation pathways. Upon pheromone induction, the mitogen-activated protein kinases, Fus3 and Kss1, activate Ste12 by relieving the repression of two functionally redundant Ste12 inhibitors, Dig1 and Dig2. Mating genes are controlled by the Ste12/Dig1/Dig2 complex through Ste12-binding sites, whereas filamentation genes are regulated by the Tec1/Ste12/Dig1 complex through Tec1-binding sites. The two Ste12 complexes are mutually exclusive. During pheromone response, Tec1 is degraded upon phosphorylation by Fus3, preventing cross-activation of the filamentation pathway. Here, we show that a stable Tec1 also impairs the induction of mating genes. A mathematical model is developed to capture the dynamic formation of the two Ste12 complexes and their interactions with pathway-specific promoters. By model simulations and experimentation, we show that excess Tec1 can impair the mating transcriptional output because of its ability to sequester Ste12, and because of a novel function of Dig2 for the transcription of mating genes. We suggest that Fus3-triggered Tec1 degradation is an important part of the transcriptional induction of mating genes during the pheromone response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.