ArticleMolecular therapy : the journal of the American Society of Gene Therapy2008
Targeting mRNA stability arrests inflammatory bone loss.
Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway.Journal of advanced research · 2025Article
- Tristetraprolin regulates the skeletal phenotype and osteoclastogenic potential through monocytic myeloid-derived suppressor cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- The nexus between RNA-binding proteins and their effectors.Nature reviews. Genetics · 2023Review
- Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused byFrontiers in microbiology · 2022Article
- Post-Transcriptional Regulation of Immune Responses and Inflammatory Diseases by RNA-Binding ZFP36 Family Proteins.Frontiers in immunology · 2021Review
- RBPs Play Important Roles in Vascular Endothelial Dysfunction Under Diabetic Conditions.Frontiers in physiology · 2018Review
- Silk Fibroin-Alginate-Hydroxyapatite Composite Particles in Bone Tissue Engineering Applications In Vivo.International journal of molecular sciences · 2017Article
- Tristetraprolin as a Therapeutic Target in Inflammatory Disease.Trends in pharmacological sciences · 2016Review
- Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis.Molecular oral microbiology · 2016Review
- Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cell- and Gene- Based Therapeutics for Periodontal Regeneration.International journal of preventive medicine · 2015Review
- Post-transcriptional control of cytokine gene expression in health and disease.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Article
- Luteolin inhibits inflammatory responses via p38/MK2/TTP-mediated mRNA stability.Molecules (Basel, Switzerland) · 2013Article
- Multiple functions of tristetraprolin/TIS11 RNA-binding proteins in the regulation of mRNA biogenesis and degradation.Cellular and molecular life sciences : CMLS · 2013Review
- Genetic polymorphisms in RNA binding proteins contribute to breast cancer survival.International journal of cancer · 2013Article
- MKP-1 is essential for canonical vitamin D-induced signaling through nuclear import and regulates RANKL expression and function.Molecular endocrinology (Baltimore, Md.) · 2012Article
- 3,6'-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit.Journal of neurochemistry · 2012Article
- Control of cytokine mRNA expression by RNA-binding proteins and microRNAs.Journal of dental research · 2012Review
- Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease.Journal of neuroinflammation · 2012Article
- Posttranscriptional Gene Regulation: Novel Pathways for Glucocorticoids' Anti-inflammatory Action.Translational medicine @ UniSa · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Many proinflammatory cytokines contain adenylate-uridylate-rich elements (AREs) within the 3'-untranslated region (UTR) that confer rapid mRNA destabilization. During the inflammatory response, cytokine mRNA are stabilized via complex interactions with RNA-binding proteins controlled by phosphorylation via multiple signaling pathways including the mitogen-activated protein kinases (MAPKs). In the absence of inflammation, a key cytokine-regulating RNA-binding protein, tristetraprolin (TTP), shuttles mRNA transcripts to degradation machinery in order to maintain low levels of inflammatory cytokines. Using this general model of mRNA decay, over expression of TTP was evaluated in an experimental model of inflammatory bone loss to determine whether altering cytokine mRNA stability has an impact in pathological bone resorption. Using adenoviral-delivered TTP, significant reductions of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and prostaglandin (PG)E(2) were observed in vitro through a mechanism consistent with targeting mRNA stability. In vivo analysis indicates a significant protective effect from inflammation-induced bone loss and inflammatory infiltrate in animals overexpressing TTP compared with reporter controls. These findings provide experimental evidence that mRNA stability is a valid therapeutic target in inflammatory bone loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.