ReviewJournal of the Royal Society, Interface2008
Microfluidic single-cell analysis of intracellular compounds.
Review in Journal of the Royal Society, Interface, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Gut-on-a-chip platforms: Bridging in vitro and in vivo models for advanced gastrointestinal research.Physiological reports · 2025Review
- Integrating optical and electrical sensing with machine learning for advanced particle characterization.Biomedical microdevices · 2024Article
- Article
- Modular microfluidics for life sciences.Journal of nanobiotechnology · 2023Review
- Recent advances for cancer detection and treatment by microfluidic technology, review and update.Biological procedures online · 2022Review
- Mechanically Induced Cavitation in Biological Systems.Life (Basel, Switzerland) · 2021Review
- Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks.Proceedings. Mathematical, physical, and engineering sciences · 2020Review
- Coupling Microfluidic Platforms, Microfabrication, and Tissue Engineered Scaffolds to Investigate Tumor Cells Mechanobiology.Micromachines · 2019Review
- Internalization and accumulation of model lignin breakdown products in bacteria and fungi.Biotechnology for biofuels · 2019Article
- Lignocellulose-based analytical devices: bamboo as an analytical platform for chemical detection.Scientific reports · 2015Article
- Investigation of nerve injury through microfluidic devices.Journal of the Royal Society, Interface · 2014Review
- Biomimetic tumor microenvironment on a microfluidic platform.Biomicrofluidics · 2013Review
- Single cell genomics of the brain: focus on neuronal diversity and neuropsychiatric diseases.Current genomics · 2012Article
- High Throughput Micropatterning of Optical Oxygen Sensor for Single Cell Analysis.IEEE sensors journal · 2012Article
- Microfabricated electrochemical cell-based biosensors for analysis of living cells in vitro.Biosensors · 2012Review
- Article
- Single-cell chemical lysis on microfluidic chips with arrays of microwells.Sensors (Basel, Switzerland) · 2012Article
- Nanocapillary electrophoretic electrochemical chip: towards analysis of biochemicals released by single cells.Interface focus · 2011Article
- Multiplexed protein analysis using encoded antibody-conjugated microbeads.Journal of the Royal Society, Interface · 2011Article
- Chemical analysis of single cells.Analytical chemistry · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological analyses traditionally probe cell ensembles in the range of 103-106 cells, thereby completely averaging over relevant individual cell responses, such as differences in cell proliferation, responses to external stimuli or disease onset. In past years, this fact has been realized and increasing interest has evolved for single-cell analytical methods, which could give exciting new insights into genomics, proteomics, transcriptomics and systems biology. Microfluidic or lab-on-a-chip devices are the method of choice for single-cell analytical tools as they allow the integration of a variety of necessary process steps involved in single-cell analysis, such as selection, navigation, positioning or lysis of single cells as well as separation and detection of cellular analytes. Along with this advantageous integration, microfluidic devices confine single cells in compartments near their intrinsic volume, thus minimizing dilution effects and increasing detection sensitivity. This review overviews the developments and achievements of microfluidic single-cell analysis of intracellular compounds in the past few years, from proof-of-principle devices to applications demonstrating a high biological relevance.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.