Trial reportNeuropsychologia2008
Neural correlates of STN DBS-induced cognitive variability in Parkinson disease.
Trial report in Neuropsychologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 69 citations in OpenAlex.
- Modulation of motor inhibition by subthalamic stimulation in obsessive-compulsive disorder.Translational psychiatry · 2016Trial
- Motor and Nonmotor Circuitry Activation Induced by Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease: Intraoperative Functional Magnetic Resonance Imaging for Deep Brain Stimulation.Mayo Clinic proceedings · 2015Trial
- Delayed hemorrhage following deep brain stimulation device placement in a patient with Parkinson's disease and lupus anticoagulant syndrome: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Prediction of Deep Brain Stimulation Outcome in Parkinson's Disease With Connectome Based on Hemispheric Asymmetry.Frontiers in neuroscience · 2021Article
- Review
- The effect of STN DBS on modulating brain oscillations: consequences for motor and cognitive behavior.Experimental brain research · 2020Review
- Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals.Neuron · 2020Article
- Subthalamic Nucleus Subregion Stimulation Modulates Inhibitory Control.Cerebral cortex communications · 2020Article
- Bilateral subthalamic nucleus deep brain stimulation increases fixational saccades during movement preparation: evidence for impaired preparatory set.Experimental brain research · 2019Article
- ESM-CT: a precise method for localization of DBS electrodes in CT images.Journal of neuroscience methods · 2018Article
- Mapping movement, mood, motivation and mentation in the subthalamic nucleus.Royal Society open science · 2018Article
- Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease.Neurobiology of aging · 2018Article
- Feasibility ofEJNMMI research · 2018Article
- l-Dopa/carbidopa intestinal gel and subthalamic nucleus stimulation: Effects on cognition and behavior.Brain and behavior · 2017Article
- Focused stimulation of dorsal subthalamic nucleus improves reactive inhibitory control of action impulses.Neuropsychologia · 2017Article
- The effects of unilateral versus bilateral subthalamic nucleus deep brain stimulation on prosaccades and antisaccades in Parkinson's disease.Experimental brain research · 2017Article
- Response inhibition in Parkinson's disease: a meta-analysis of dopaminergic medication and disease duration effects.NPJ Parkinson's disease · 2017Review
- Article
- Network effects of deep brain stimulation.Journal of neurophysiology · 2015Review
- Functional anatomy of subthalamic nucleus stimulation in Parkinson disease.Annals of neurology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson disease (PD) improves motor function, it has variable effects on working memory (WM) and response inhibition (RI) performance. The purpose of this study was to determine the neural correlates of STN DBS-induced variability in cognitive performance.
methodsWe measured bilateral STN DBS-induced blood flow changes (PET and [(15)O]-water on one day) in the supplementary motor area (SMA), dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), and right inferior frontal cortex (rIFC) as well as in exploratory ROIs defined by published meta-analyses. STN DBS-induced WM and RI changes (Spatial Delayed Response and Go-No-Go on the next day) were measured in 24 PD participants. On both days, participants withheld PD medications overnight and conditions (OFF vs. ON) were administered in a counterbalanced, double-blind manner.
resultsAs predicted, STN DBS-induced DLPFC blood flow change correlated with change in WM, but not RI performance. Furthermore, ACC blood flow change correlated with change in RI but not WM performance. For both relationships, increased blood flow related to decreased cognitive performance in response to STN DBS. Of the exploratory regions, only blood flow changes in DLPFC and ACC were correlated with performance.
conclusionsThese results demonstrate that variability in the effects of STN DBS on cognitive performance relates to STN DBS-induced cortical blood flow changes in DLPFC and ACC. This relationship highlights the need to further understand the factors that mediate the variability in neural and cognitive response to STN DBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.