Trial reportThe British journal of general practice : the journal of the Royal College of General Practitioners2008
Can type 2 diabetes be prevented in UK general practice? A lifestyle-change feasibility study (ISAIAH).
Trial report in The British journal of general practice : the journal of the Royal College of General Practitioners, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Lower-Intensity Interventions for Prediabetes: A Systematic Review.American journal of preventive medicine · 2023Pooled it
- The Effectiveness and Cost of Lifestyle Interventions Including Nutrition Education for Diabetes Prevention: A Systematic Review and Meta-Analysis.Journal of the Academy of Nutrition and Dietetics · 2017Pooled it
- Reduction of diabetes risk in routine clinical practice: are physical activity and nutrition interventions feasible and are the outcomes from reference trials replicable? A systematic review and meta-analysis.BMC public health · 2010Pooled it
- Feasibility and effectiveness of the implementation of a primary prevention programme for type 2 diabetes in routine primary care practice: a phase IV cluster randomised clinical trial.BMC family practice · 2012Trial
- Naturally Occurring Endocrine Disorders in Non-Human Primates: A Comprehensive Review.Animals : an open access journal from MDPI · 2022Review
- Article
- Primary health care-level interventions targeting health literacy and their effect on weight loss: a systematic review.BMC obesity · 2015Article
- Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: modulation of inflammation and oxidative stress.Biologics : targets & therapy · 2011Article
- Preventive advice given by patients with type 2 diabetes to their offspring.The British journal of general practice : the journal of the Royal College of General Practitioners · 2009Article
- Diabetes prevention.The British journal of general practice : the journal of the Royal College of General Practitioners · 2008Article
- Diabetes prevention.The British journal of general practice : the journal of the Royal College of General Practitioners · 2008Article
- Reducing the rise in type 2 diabetes.The British journal of general practice : the journal of the Royal College of General Practitioners · 2008Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increasing incidence of type 2 diabetes mellitus is attributed to increasing weight, reduced physical activity, and poor diet quality. Lifestyle change in patients with pre-diabetes can reduce progression to diabetes but this is difficult to achieve in practice.
aimTo study the effectiveness of a lifestyle-change intervention for pre-diabetes in general practice. DESIGN OF THE STUDY: A feasibility study.
settingA medium-sized general practice in Sheffield.
methodParticipants were 33 patients with pre-diabetes. The intervention was a 6-month delayed entry comparison of usual treatment with a lifestyle-change programme: increased exercise and diet change, either reduction in glycaemic load, or reduced-fat diet. The main outcome measures were weight, body mass index (BMI), waist circumference, fasting glucose, lipid profile, and nutrition.
resultsA statistically significant difference was observed between control and intervention groups in three markers for risk of progression to diabetes (weight (P<0.03), BMI (P<0.03), and waist circumference (P<0.001)). No significant differences in fasting glucose or lipid profiles were seen. Aggregated data showed a statistically non-significant improvement in all the measures of metabolic risk of progression to diabetes in the low-glycaemic-load group when compared with a low-fat-diet group (P>0.05). Significant total energy, fat, and carbohydrate intake reduction was achieved and maintained in both groups.
conclusionA lifestyle-change intervention feasibility programme for pre-diabetic patients was implemented in general clinical practice. The potential of a low-glycaemic-load diet to be more effective than a low-fat diet in promoting change in the features associated with progression to diabetes is worthy of further investigation.
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