ArticleGenes to cells : devoted to molecular & cellular mechanisms2008
Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of Senseless.
Article in Genes to cells : devoted to molecular & cellular mechanisms, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor.Scientific reports · 2022Article
- Repurposing the lineage-determining transcription factor Atoh1 without redistributing its genomic binding sites.Frontiers in cell and developmental biology · 2022Article
- Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors.Cell reports · 2021Article
- Hexagonal patterning of the Drosophila eye.Developmental biology · 2021Review
- Transcription Factor Reprogramming in the Inner Ear: Turning on Cell Fate Switches to Regenerate Sensory Hair Cells.Frontiers in cellular neuroscience · 2021Article
- Daughterless, theDisease models & mechanisms · 2020Article
- All in the family: proneural bHLH genes and neuronal diversity.Development (Cambridge, England) · 2018Review
- Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain.Neural development · 2016Article
- The Role of Atonal Factors in Mechanosensory Cell Specification and Function.Molecular neurobiology · 2015Article
- The role of Atonal transcription factors in the development of mechanosensitive cells.Seminars in cell & developmental biology · 2013Review
- Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit.Molecular and cellular neurosciences · 2013Article
- Beyond generalized hair cells: molecular cues for hair cell types.Hearing research · 2013Review
- Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repression.Molecular and cellular biology · 2012Article
- The SUMO pathway promotes basic helix-loop-helix proneural factor activity via a direct effect on the Zn finger protein senseless.Molecular and cellular biology · 2012Article
- Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: function, regulation, and context dependency.Journal of the Association for Research in Otolaryngology : JARO · 2012Review
- Reactive oxygen species and the neuronal fate.Cellular and molecular life sciences : CMLS · 2012Review
- Discrete regulatory regions control early and late expression of D-Pax2 during external sensory organ development.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The role of bHLH genes in ear development and evolution: revisiting a 10-year-old hypothesis.Cellular and molecular life sciences : CMLS · 2010Review
- Atonal, Senseless, and Abdominal-A regulate rhomboid enhancer activity in abdominal sensory organ precursors.Developmental biology · 2010Article
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Authors and funding
4 authors.
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Abstract
The question of how proneural bHLH transcription factors recognize and regulate their target genes is still relatively poorly understood. We previously showed that Scute (Sc) and Atonal (Ato) target genes have different cognate E box motifs, suggesting that specific DNA interactions contribute to differences in their target gene specificity. Here we show that Sc and Ato proteins (in combination with Daughterless) can activate reporter gene expression via their cognate E boxes in a non-neuronal cell culture system, suggesting that the proteins have strong intrinsic abilities to recognize different E box motifs in the absence of specialized cofactors. Functional comparison of E boxes from several target genes and site-directed mutagenesis of E box motifs suggests that specificity and activity require further sequence elements flanking both sides of the previously identified E box motifs. Moreover, the proneural cofactor, Senseless, can augment the function of Sc and Ato on their cognate E boxes and therefore may contribute to proneural specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.