ArticleBiochemical and biophysical research communications2008
VASP involvement in force-mediated adherens junction strengthening.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
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- Assessment of MRI to estimate metastatic dissemination risk and prometastatic effects of chemotherapy.NPJ breast cancer · 2022Article
- Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function.Communications biology · 2020Article
- Probing compression versus stretch activated recruitment of cortical actin and apical junction proteins using mechanical stimulations of suspended doublets.APL bioengineering · 2018Article
- Characterization of cell-cell junction changes associated with the formation of a strong endothelial barrier.Tissue barriers · 2018Article
- Resolving the cadherin-F-actin connection.Nature cell biology · 2016Article
- Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: implications for cell migration.Cell adhesion & migration · 2015Article
- Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens.Current biology : CB · 2014Article
- iTRAQ based quantitative proteomics approach validated the role of calcyclin binding protein (CacyBP) in promoting colorectal cancer metastasis.Molecular & cellular proteomics : MCP · 2013Article
- The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche.Development (Cambridge, England) · 2012Article
- Lessons from the endothelial junctional mechanosensory complex.F1000 biology reports · 2012Article
- Cell-cell interactions mediate the response of vascular smooth muscle cells to substrate stiffness.Biophysical journal · 2011Article
- Article
- Conserved F-actin dynamics and force transmission at cell adhesions.Current opinion in cell biology · 2010Review
- Dissecting cell adhesion cross-talk with micropatterns.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Mechanical tugging force regulates the size of cell-cell junctions.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Actin polymerization in differentiated vascular smooth muscle cells requires vasodilator-stimulated phosphoprotein.American journal of physiology. Cell physiology · 2010Article
- FUNCTIONALIZED, SWELLABLE HYDROGEL LAYERS AS A PLATFORM FOR CELL STUDIES.Advanced functional materials · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Strengthening of cell-matrix adhesions in response to applied force has been well documented. However, while implied by various lines of evidence, the force-mediated strengthening of cell-cell adhesions has not been directly demonstrated. In the current study, we present results consistent with force strengthening in adherens junctions, obtained by application of different force profiles to VE-cadherin-coated magnetic beads attached to endothelial cells. When force is ramped from a low to high value over time, fewer beads detach than with the immediate application of high force. Cells treated with cytochalasin D or lacking Ena/VASP activity show similar levels of detachment relative to controls, but force strengthening is lost. Further, cells overexpressing VASP show stronger adhesion in response to low and high force, but adhesion weakening in response to ramped forces. These results indicate that force-mediated adhesion strengthening occurs in endothelial adherens junctions and that dynamic VASP activity is necessary for this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.