Evidence map›Paper›PMID 18680436›Full record

ReviewAnnual review of genetics2008

The take and give between retrotransposable elements and their hosts.

Arthur Beauregard, M Joan Curcio, Marlene Belfort

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
22.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 170 citations in OpenAlex.

  1. Article
  2. Article
  3. Affinity-Based Interactome Analysis of Endogenous LINE-1 Macromolecules.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  4. Article
  5. Stealing genes and facing consequences.Science (New York, N.Y.) · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. HSV-1 and Endogenous Retroviruses as Risk Factors in Demyelination.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Comparative Genomics: Insights on the Pathogenicity and Lifestyle ofInternational journal of molecular sciences · 2021
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Arthur BeauregardNew York State Department of Health, Center for Medical Sciences, Albany, New York 12208, 12201-2002, USA. beaureg@wadsworth.org
M Joan Curcio
Marlene Belfort
New York State Department of Health · USUniversity at Albany, State University of New York · US

Funding

SELF-SPLICING INTEINS: FUNCTION, EVOLUTION, APPLICATIONR01GM044844 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 1990 to 2019
$8.9M
SELF-SPLICING INTRONS IN THE PHAGE T4/E COLI SYSTEMR01GM039422 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 1988 to 2019
$5.3M
INTRON DYNAMICS IN BACTERIAR37GM039422 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 2001 to 2010
$4.0M
REGULATION OF RETROTRANSPOSITION IN S. CEREVISIAER01GM052072 · NIGMS · WADSWORTH CENTER · PI CURCIO, M JOAN · 2000 to 2013
$3.3M
Effect of APOBEC3G on retroviruses and retrotransposonsR01AI065301 · NIAID · DUKE UNIVERSITY · PI CULLEN, BRYAN R. · 2005 to 2009
$1.7M
REGULATION OF RETROTRANSPOSITION IN S CEREVISIAER29GM052072 · NIGMS · WADSWORTH CENTER · PI CURCIO, M JOAN · 1995 to 1999
–
NIAID NIH HHS AI65301NIAID NIH HHS R01 AI065301NIGMS NIH HHS GM39422NIGMS NIH HHS GM44844NIGMS NIH HHS GM52072NIGMS NIH HHS R01 GM039422NIGMS NIH HHS R01 GM044844NIGMS NIH HHS R01 GM052072NIGMS NIH HHS R29 GM052072NIGMS NIH HHS R37 GM039422
6 · The paper itself

Abstract

Retrotransposons mobilize via RNA intermediates and usually carry with them the agent of their mobility, reverse transcriptase. Retrotransposons are streamlined, and therefore rely on host factors to proliferate. However, retrotransposons are exposed to cellular forces that block their paths. For this review, we have selected for our focus elements from among target-primed (TP) retrotransposons, also called non-LTR retrotransposons, and extrachromosomally-primed (EP) retrotransposons, also called LTR retrotransposons. The TP retrotransposons considered here are group II introns, LINEs and SINEs, whereas the EP elements considered are the Ty and Tf retrotransposons, with a brief comparison to retroviruses. Recurring themes for these elements, in hosts ranging from bacteria to humans, are tie-ins of the retrotransposons to RNA metabolism, DNA replication and repair, and cellular stress. Likewise, there are parallels among host-cell defenses to combat rampant retrotransposon spread. The interactions between the retrotransposon and the host, and their coevolution to balance the tension between retrotransposon proliferation and host survival, form the basis of this review.

Indexed as

AnimalsBacteriaDNA DamageDNA RepairDNA ReplicationGene SilencingHumansIntronsLong Interspersed Nucleotide ElementsMammalsModels, GeneticRetroelementsRNA Processing, Post-TranscriptionalShort Interspersed Nucleotide ElementsTelomereYeastsRetroelements

Identifiers

PMID18680436
PMCPMC2665727
OpenAlexW2153382500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.