ArticleWorld journal of gastroenterology2008
Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Association between TLR2 and TLR4 Gene Polymorphisms and the Susceptibility to Inflammatory Bowel Disease: A Meta-Analysis.PloS one · 2015Pooled it
- Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis.BMC gastroenterology · 2014Pooled it
- Pooled it
- Common NOD2/CARD15 and TLR4 Polymorphisms Are Associated with Crohn's Disease Phenotypes in Southeastern Brazilians.Digestive diseases and sciences · 2016Article
- The common NOD2/CARD15 variant P268S in patients with non-infectious uveitis: a cohort study.Pediatric rheumatology online journal · 2015Article
- NOD2/CARD15 gene mutations in North Algerian patients with inflammatory bowel disease.World journal of gastroenterology · 2015Article
- Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease.Gastroenterology research and practice · 2015Review
- Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.World journal of gastrointestinal pathophysiology · 2014Review
- Inflammatory bowel disease in pediatric and adolescent patients: a biomolecular and histopathological review.World journal of gastroenterology · 2014Article
- NOD2 gene mutations in ulcerative colitis: useless or misunderstood?International journal of colorectal disease · 2014Article
- Intestinal barrier in inflammatory bowel disease.World journal of gastroenterology · 2014Review
- Genetic susceptibility to idiopathic membranous nephropathy in high-prevalence Area, Taiwan.BioMedicine · 2014Article
- Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: its expression and effects in the ten most common cancers.OncoTargets and therapy · 2013Review
- Role of Salmonella enterica exposure in Chilean Crohn's disease patients.World journal of gastroenterology · 2013Article
- Readressing the role of Toll-like receptor-4 alleles in inflammatory bowel disease: colitis, smoking, and seroreactivity.Digestive diseases and sciences · 2013Article
- The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course.PPAR research · 2012Article
- Pulmonary-intestinal cross-talk in mucosal inflammatory disease.Mucosal immunology · 2012Review
- Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort.PloS one · 2010Article
- Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.
methodsAllele and genotype frequencies of NOD2/CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD patients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed.
resultsNOD2/CARD15 R702W mutation was significantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No significant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no significant association with G908R variant was found. L1007finsC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05).
conclusionThese findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/CARD15, but not TLR4 SNPs, are associated with increased risk of CD.
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