ReviewHuman psychopharmacology2008
Circadian rhythm disturbances in depression.
Review in Human psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 233 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
233 citing papers in PubMed, 8 syntheses or guidelines pooled it, 625 citations in OpenAlex.
- Does insomnia treatment prevent depression?Sleep · 2023Pooled it
- Relationship between night-sleep duration and risk for depression among middle-aged and older people: A dose-response meta-analysis.Frontiers in physiology · 2023Pooled it
- Pooled it
- Association between Daily Pattern of Physical Activity and Depression: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Pooled it
- High circadian stimulus lighting therapy for depression: Meta-analysis of clinical trials.Frontiers in neuroscience · 2022Pooled it
- Diurnal preference and depressive symptomatology: a meta-analysis.Scientific reports · 2021Pooled it
- Research Hot Spots and Trends on Melatonin From 2000 to 2019.Frontiers in endocrinology · 2021Pooled it
- Impact of Nano-Selenium supplementation on the JAK/STAT signaling pathway in major depressive disorder: a Triple-Blind, randomized controlled trial.BMC psychiatry · 2025Trial
- Uncovering complexity details in actigraphy patterns to differentiate the depressed from the non-depressed.Scientific reports · 2021Trial
- The effect of bright light therapy on depressive symptoms in adults with intellectual disabilities: Results of a multicentre randomized controlled trial.Journal of applied research in intellectual disabilities : JARID · 2020Trial
- Effects of bright light therapy for depression during pregnancy: a randomised, double-blind controlled trial.BMJ open · 2020Trial
- Trial
- Sleep disturbances as early indicators of incident psychiatric disease.European archives of psychiatry and clinical neuroscience · 2026Article
- Electronic self-monitored morning depression scores are related to sleep timing and sleep length in depressed patients.Npj biological timing and sleep · 2026Article
- Seasonal Mental Health Symptoms Amongst Former Criminal Legal System-Involved Adolescents.Journal of adolescence · 2026Article
- Test of the reward/circadian rhythm dysregulation model of risk for bipolar spectrum disorders at a micro time scale using multilevel moderated mediation.Journal of psychopathology and clinical science · 2026Article
- The association of vitamin D deficiency with depressive disorders in patients with eating disorders: a cross-sectional study.Journal of eating disorders · 2026Article
- Hyperuricemia as a Biomarker for Circadian Syndrome: A Cross-Sectional Study.Clocks & sleep · 2026Article
- Temporal Dynamics of Sleep During Bright-Light Therapy for Depression and Their Relation to Symptom Improvement.Clocks & sleep · 2026Article
173 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this article is to review progress in understanding the mechanisms that underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of depression.
methodsLiterature was selected principally by Medline searches, and additional reports were identified based on ongoing research activities in the authors' laboratory.
resultsMany physiological processes show circadian rhythms of activity. Sleep and waking are the most obvious circadian rhythms in mammals. There is considerable evidence that circadian and sleep disturbances are important in the pathophysiology of mood disorders. Depressed patients often show altered circadian rhythms, sleep disturbances, and diurnal mood variation. Chronotherapies, including bright light exposure, sleep deprivation, and social rhythm therapies, may be useful adjuncts in non-seasonal and seasonal depression. Antidepressant drugs have marked effects on circadian processes and sleep.
conclusionsRecent progress in understanding chronobiological and sleep regulation mechanisms may provide novel insights and avenues into the development of new pharmacological and behavioral treatment strategies for mood disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.