ArticleJournal of chemical ecology2008
Activated chemical defense in marine sponges--a case study on Aplysinella rhax.
Article in Journal of chemical ecology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Marine Bromotyrosine Derivatives in Spotlight: Bringing Discoveries and Biological Significance.Marine drugs · 2024Review
- Impact of Marine Chemical Ecology Research on the Discovery and Development of New Pharmaceuticals.Marine drugs · 2023Review
- Psammaplysins: Insights from Natural Sources, Structural Variations, and Pharmacological Properties.Marine drugs · 2022Review
- Targeted Isolation of Antibiotic Brominated Alkaloids from the Marine SpongeMarine drugs · 2022Article
- Insights into phosphatase-activated chemical defense in a marine sponge holobiont.RSC chemical biology · 2021Article
- Application of Networking Approaches to Assess the Chemical Diversity, Biogeography, and Pharmaceutical Potential of Verongiida Natural Products.Marine drugs · 2021Article
- A Soft Spot for Chemistry-Current Taxonomic and Evolutionary Implications of Sponge Secondary Metabolite Distribution.Marine drugs · 2021Review
- Presence of Bromotyrosine Alkaloids in Marine Sponges Is Independent of Metabolomic and Microbiome Architectures.mSystems · 2021Article
- Opisthobranch grazing results in mobilisation of spherulous cells and re-allocation of secondary metabolites in the sponge Aplysina aerophoba.Scientific reports · 2020Article
- Marine-Derived Natural Lead Compound Disulfide-Linked Dimer Psammaplin A: Biological Activity and Structural Modification.Marine drugs · 2019Review
- Phytochemical and Analytical Characterization of Novel Sulfated Coumarins in the Marine Green MacroalgaMolecules (Basel, Switzerland) · 2018Article
- Determination of the Halogenated Skeleton Constituents of the Marine Demosponge Ianthella basta.Marine drugs · 2017Article
- Chemoreception of the Seagrass Posidonia Oceanica by Benthic Invertebrates is Altered by Seawater Acidification.Journal of chemical ecology · 2015Article
- New antimicrobial bromotyrosine analogues from the sponge Pseudoceratina purpurea and its predator Tylodina corticalis.Marine drugs · 2015Article
- Article
- Effects of toxic compounds in Montipora capitata on exogenous and endogenous zooxanthellae performance and fertilization success.PloS one · 2015Article
- Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont.Nature chemical biology · 2014Article
- Natural products: Sponge symbionts play defense.Nature chemical biology · 2014Article
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Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Activated chemical defense, i.e., the rapid conversion of precursor molecules to defensive compounds following tissue damage, has been well documented for terrestrial and marine plants; but evidence for its presence in sessile marine invertebrates remains scarce. We observed a wound-activated conversion of psammaplin A sulfate to psammaplin A in tissue of the tropical sponge Aplysinella rhax. The conversion is rapid (requiring only seconds), the turnover rate increases with increasing wounding activity (e.g., approximately 20% after tissue stabbing vs. approximately 85% after tissue grinding), and is likely enzyme-catalyzed (no reaction in the absence of water and inhibition of the conversion by heat). Fish feeding assays with the pufferfish Canthigaster solandri, an omnivorous sponge predator, revealed an increased anti-feeding activity by the conversion product psammaplin A compared to the precursor psammaplin A sulfate. We propose that the wound-activated formation of psammaplin A in A. rhax is an activated defense targeted against predator species that are not efficiently repelled by the sponge's constitutive chemical defense. Recent observations of conversion reactions also in other sponge species indicate that more activated defenses may exist in this phylum. Based on the findings of this study, we address the question whether activated defenses may be more common in sponges--and perhaps also in other sessile marine invertebrates--than hitherto believed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.