ArticleFunctional & integrative genomics2009
Phenylalanine ammonia-lyase (PAL) and cinnamate 4-hydroxylase (C4H) and catechins (flavan-3-ols) accumulation in tea.
Article in Functional & integrative genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 209 citations in OpenAlex.
- Integrated Metabolomic and Transcriptomic Analysis of Phenylpropanoid Biosynthesis inCurrent issues in molecular biology · 2026Article
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- Exogenous curcumin alleviates salt stress in lavender plants: a physiological and biochemical investigation.BMC plant biology · 2025Article
- The distinct characteristics of the endophytic microbiome and metabolome within the root system result in varying abilities of watermelon resistance against Fusarium wilt.BMC plant biology · 2025Article
- Influencing Factors and Regulatory Mechanisms of Fresh Tea Leaf Quality: A Review.Foods (Basel, Switzerland) · 2025Review
- Germination-Induced Changes in the Nutritional, Bioactive, and Digestive Properties of Lima Bean (Foods (Basel, Switzerland) · 2025Article
- Revealing novel insights into the improvement of greenhouse tea quality through exogenous substance interventions using targeted and untargeted metabolomics and microbial community analyses.Food chemistry: X · 2025Article
- Genome-wide characterization of PAL, C4H, and 4CL genes regulating the phenylpropanoid pathway in Vanilla planifolia.Scientific reports · 2025Article
- Consumer traits of common beans: a global and regional perspective on seed coat darkening, cooking time, protein, and mineral content.Frontiers in nutrition · 2025Review
- Genome-wide identification and expression analysis of Phenylalanine Ammonia-Lyase (PAL) in cucumber.PloS one · 2025Article
- Biosynthesis of Phenolic Compounds ofInternational journal of molecular sciences · 2024Article
- Transcriptomic and Metabolic Analysis Reveals Genes and Pathways Associated with Flesh Pigmentation in Potato (Current issues in molecular biology · 2024Article
- ABA and MeJA Induced Catechin and Epicatechin Biosynthesis and Accumulation inPlants (Basel, Switzerland) · 2024Article
- Catechin promotes the germination of Pistacia chinensis seeds via GA biosynthesis.Annals of botany · 2024Article
- Synthesis and evaluation of pyridine-3-carboxamide analogs as effective agents against bacterial wilt in tomatoes.Scientific reports · 2024Article
- Comprehensive review of mapping climate change impacts on tea cultivation: bibliometric and content analysis of trends, influences, adaptation strategies, and future directions.Frontiers in plant science · 2024Review
- Alleviation of Adverse Effects of Drought Stress on Growth and Nitrogen Metabolism in Mungbean (Plants (Basel, Switzerland) · 2023Article
- GABA Application Enhances Drought Stress Tolerance in Wheat Seedlings (Plants (Basel, Switzerland) · 2023Article
- Impact of Light and Dark Treatment on Phenylpropanoid Pathway Genes, Primary and Secondary Metabolites inLife (Basel, Switzerland) · 2023Article
- Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenylalanine ammonia-lyase and cinnamate 4-hydroxylase are important enzymes in allocating significant amounts of carbon from phenylalanine into the biosynthesis of several important secondary metabolites. Tea is an important crop of commerce known for its beverage and medicinally important flavonoid compounds, mainly catechins. As metabolic flux for the operation of the flavonoid pathway is maintained through the activities of PAL and C4H, thus, catechins biosynthesis in tea is critically dependent on the products of these enzymes. We examined the expression of PAL and C4H. Sequence encoding CsPAL was isolated from tea by polymerase chain reaction using sequence information available at the NCBI GenBank. Sequence encoding C4H was isolated from tea by using differential display of mRNA and rapid amplification of cDNA ends technology. CsC4H (AY641731) comprised of 1,352 bp full-length cDNA with open reading frame of 1,173 bp encoding 390 amino acids. Catechin contents decreased in response to drought stress (DS), abscisic acid (ABA), and gibberellic acid (GA(3)) treatments but increased in response to wounding. The expression of CsPAL and CsC4H showed the same behavior under the above treatments and was also in accordance with the catechin contents. A positive correlation between catechin contents and gene expression suggested a critical role of the enzymes in catechins biosynthesis and a crosstalk between phenylpropanoid and flavonoid pathways.
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