ArticlePflugers Archiv : European journal of physiology2009
PKD1 haploinsufficiency is associated with altered vascular reactivity and abnormal calcium signaling in the mouse aorta.
Article in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Aortic Dilatation in Children and Young People With ADPKD.Kidney international reports · 2024Article
- Vascular polycystin proteins in health and disease.Microcirculation (New York, N.Y. : 1994) · 2024Review
- Radial pseudoaneurysm following coronary angiography in a patient with autosomal dominant polycystic kidney disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Vascular Dysfunction in Polycystic Kidney Disease: A Mini-Review.Journal of vascular research · 2023Review
- Modulation of polycystic kidney disease by G-protein coupled receptors and cyclic AMP signaling.Cellular signalling · 2020Review
- Fundamental insights into autosomal dominant polycystic kidney disease from human-based cell models.Pediatric nephrology (Berlin, Germany) · 2019Article
- Polycystic kidney disease.Nature reviews. Disease primers · 2018Review
- New Insights into the Molecular Mechanisms Targeting Tubular Channels/Transporters in PKD Development.Kidney diseases (Basel, Switzerland) · 2016Review
- Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models.Scientific reports · 2016Article
- Vascular complications in autosomal dominant polycystic kidney disease.Nature reviews. Nephrology · 2015Review
- Vasopressin and disruption of calcium signalling in polycystic kidney disease.Nature reviews. Nephrology · 2015Review
- Strategies targeting cAMP signaling in the treatment of polycystic kidney disease.Journal of the American Society of Nephrology : JASN · 2014Review
- Polycystins and cellular Ca2+ signaling.Cellular and molecular life sciences : CMLS · 2013Review
- Does kidney disease cause hypertension?Current hypertension reports · 2013Review
- Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone.American journal of physiology. Heart and circulatory physiology · 2013Article
- Polycystins, focal adhesions and extracellular matrix interactions.Biochimica et biophysica acta · 2011Review
- Polycystins and renovascular mechanosensory transduction.Nature reviews. Nephrology · 2010Review
- Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases.Clinical journal of the American Society of Nephrology : CJASN · 2010Review
- Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment.International journal of nephrology and renovascular disease · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in PKD1 are associated with autosomal dominant polycystic kidney disease (ADPKD), which leads to major cardiovascular complications. We used mice with a heterozygous deletion of Pkd1 (Pkd1+/-) and wild-type (Pkd1+/+) littermates to test whether Pkd1 haploinsufficiency is associated with a vascular phenotype in different age groups. Systolic blood pressure measured by the tail-cuff method was similar up to 20 weeks of age, but significantly higher in 30-week-old Pkd1+/- compared to Pkd1+/+. By contrast, similar telemetric recordings were obtained in unrestrained Pkd1+/- and Pkd1+/+ mice. The contractile responses evoked by KCl or phenylephrine were similar in young animals but increased in abdominal aortas of 30-week-old Pkd1+/- mice, and acetylcholine-evoked relaxation was depressed. Basal cytosolic calcium, KCl, and phenylephrine-evoked calcium signals were significantly lower in the Pkd1+/- aortas, whereas calcium release evoked by caffeine or thapsigargin was significantly larger. These changes were paralleled with a significant change in the mRNA expression of Pkd2, Trpc1, Orai1, and Serca2a in the aortas from Pkd1+/- vs. Pkd1+/+. These results are the first to indicate that haploinsufficiency in Pkd1 is associated with altered intracellular calcium homeostasis and increased vascular reactivity in the aorta with compensatory changes in transport proteins involved in the calcium signaling network.
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