ArticleOncogene2008
DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals.
Article in Oncogene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Mediation of radiation-induced bystander effect and epigenetic modification: The role of exosomes in cancer radioresistance.Heliyon · 2024Review
- Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche.Cell death & disease · 2020Article
- Coupling of cell fate selection model enhances DNA damage response and may underlie BE phenomenon.IET systems biology · 2020Article
- Radiation, inflammation and the immune response in cancer.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini Review.Frontiers in pharmacology · 2018Review
- DDR-mediated crosstalk between DNA-damaged cells and their microenvironment.Frontiers in genetics · 2015Review
- Article
- Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.Mutation research. Reviews in mutation research · 2014Review
- Ionizing radiation selectively reduces skin regulatory T cells and alters immune function.PloS one · 2014Article
- Murine Prkdc polymorphisms impact DNA-PKcs function.Radiation research · 2011Article
- Genomic instability after targeted irradiation of human lymphocytes: evidence for inter-individual differences under bystander conditions.Mutation research · 2010Article
- Global gene expression analyses of bystander and alpha particle irradiated normal human lung fibroblasts: synchronous and differential responses.BMC medical genomics · 2008Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The phenomenon by which irradiated cells influence non-irradiated neighboring cells, referred to as the bystander effect (BSE), is not well understood in terms of the underlying pathways involved. We sought to enlighten connections between DNA damage repair and the BSE. Utilizing sister chromatid exchange (SCE) frequencies as a marker of the BSE, we performed cell transfer strategies that enabled us to distinguish between generation versus reception of a bystander signal. We find that DNA-dependent Protein Kinase catalytic subunit (DNA-PKcs) and Ataxia Telangectasia Mutated (ATM) are necessary for the generation of such a bystander signal in normal human cells following gamma (gamma)-ray exposure, but are not required for its reception. Importantly, we also show that directly irradiated human cells do not respond to receipt of a bystander signal, helping to explain why the BSE is a low-dose phenomenon. These studies provide the first evidence for a role of the DNA damage response proteins DNA-PKcs and ATM specifically in the generation of a bystander signal and intercellular signaling.
Indexed as
Identifiers
18679419What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.