Evidence map›Paper›PMID 18679129›Full record

ReviewCritical care medicine2008

Influenza.

John H Beigel

Registry-linked trialAbstract readReview
In one paragraph

Review in Critical care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00858611 (VRC 307), which is not on this map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00858611 phase1completednot on this mapstarted 2009, after this paper: background citation

VRC 307: A D/B Randomized Ph. I Study of Safety/Immunogenicity of a Prime-Boost Schedule of an Investigational DNA Influenza Vaccine, Followed by the Seasonal Influenza Trivalent Inactivated Vaccine (TIV), Compared to TIV Alone in Healthy Adults

TypeinterventionalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2009 to 2010Enrolled51ConditionsInfluenza, HumanArmsVRC-FLUDNA047-00-VP, Flulaval (Registered) Seasonal Influenza Vaccine
3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Article
  3. Cycling and activated CD8BMC immunology · 2022
    Article
  4. Human Susceptibility to Influenza Infection and Severe Disease.Cold Spring Harbor perspectives in medicine · 2021
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Targeting the skin for microneedle delivery of influenza vaccine.Advances in experimental medicine and biology · 2013
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

John H BeigelNational Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA. jbeigel@niaid.nih.gov

Funding

Influenza and Emerging Infectious DiseasesZ01AI000984 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI DAVEY, RICHARD · 2007 to 2008
$2.0M
Intramural NIH HHS Z99 AI999999NIAID NIH HHS Y99 AI999999
6 · The paper itself

Abstract

objectiveInfluenza is a major concern for intensivists in all communities in the U.S. While there is considerable concern whether or not the country will be ready for a pandemic influenza, even seasonal influenza poses a major challenge to hospitals. The objective of this review is to summarize current knowledge of influenza with emphasis on the issues that intensivist will encounter.

settingIntensive care unit in a 450-bed, tertiary care, teaching hospital.

methodsSource data were obtained from a PubMed search of the medical literature. PubMed "related articles" search strategies were likewise employed frequently. SUMMARY AND

conclusionsSeasonal influenza causes more than 200,000 hospitalizations and 41,000 deaths in the U.S. every year, and is the seventh leading cause of death in the U.S. Despite this impact there is a shortcoming in knowledge of influenza among many health care workers, and a paucity of clinical data and studies to guide therapy. Intensivists need to recognize the importance of seasonal influenza as a cause of severe morbidity and mortality. This review summarizes current knowledge of the diagnosis, complications, therapy, and infection control measures associated with influenza.

Indexed as

Influenza, HumanAnimalsAntiviral AgentsBirdsDisease OutbreaksHumansInfection ControlInfluenza A virusInfluenza in BirdsReassortant VirusesSeasonsUnited StatesAntiviral Agents

Identifiers

PMID18679129
PMCPMC3431208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.