ArticleInternational journal of environmental research and public health2008
Compartmentalization of aquaporins in the human intestine.
Article in International journal of environmental research and public health, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Dysbiosis of intestinal homeostasis contribute to Whitmania pigra edema disease.Microbial biotechnology · 2023Article
- Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review.Frontiers in physiology · 2023Review
- Aquaporins Are One of the Critical Factors in the Disruption of the Skin Barrier in Inflammatory Skin Diseases.International journal of molecular sciences · 2022Review
- Traditional Chinese medicine prescription Shenling BaiZhu powder to treat ulcerative colitis: Clinical evidence and potential mechanisms.Frontiers in pharmacology · 2022Review
- Aquaporin-3 in the epidermis: more than skin deep.American journal of physiology. Cell physiology · 2020Review
- Distribution of aquaporins and sodium transporters in the gastrointestinal tract of a desert hare, Lepus yarkandensis.Scientific reports · 2019Article
- Aquaporin Expression in Colonic Mucosal Biopsies From Irritable Bowel Syndrome With Diarrhea.Clinical and translational gastroenterology · 2019Article
- Expression, Distribution and Role of Aquaporin Water Channels in Human and Animal Stomach and Intestines.International journal of molecular sciences · 2016Review
- Aquaporins in Health and Disease: An Overview Focusing on the Gut of Different Species.International journal of molecular sciences · 2016Review
- Secondary Data Analytics of Aquaporin Expression Levels in Glioblastoma Stem-Like Cells.Cancer informatics · 2015Article
- Similar connotation in chronic hepatitis B and nonalcoholic Fatty liver patients with dampness-heat syndrome.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Functional Annotation Analytics of Rhodopseudomonas palustris Genomes.Bioinformatics and biology insights · 2011Article
- Integrative sequence and tissue expression profiling of chicken and mammalian aquaporins.BMC genomics · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Improper localization of water channel proteins called aquaporins (AQP) induce mucosal injury which is implicated in Crohn's disease and ulcerative colitis. The amino acid sequences of AQP3 and AQP10 are 79% similar and belong to the mammalian aquaglyceroporin subfamily. AQP10 is localized on the apical compartment of the intestinal epithelium called the glycocalyx while AQP3 is selectively targeted to the basolateral membrane. Despite the high sequence similarity and evolutionary relatedness, the molecular mechanism involved in the polarity, selective targeting and function of AQP3 and AQP10 in the intestine is largely unknown. Our hypothesis is that the differential polarity and selective targeting of AQP3 and AQP10 in the intestinal epithelial cells is influenced by amino acid signal motifs. We performed sequence and structural alignments to determine differences in signals for localization and posttranslational glycosylation. The basolateral sorting motif "YRLL" is present in AQP3 but absent in AQP10; while Nglycosylation signals are present in AQP10 but absent in AQP3. Furthermore, the C-terminal region of AQP3 is longer compared to AQP10. The sequence and structural differences between AQP3 and AQP10 provide insights into the differential compartmentalization and function of these two aquaporins commonly expressed in human intestines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.