ArticleInfection and immunity2008
Two-partner secretion systems of Neisseria meningitidis associated with invasive clonal complexes.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Review
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- Folding Control in the Path of Type 5 Secretion.Toxins · 2021Review
- Construction of a complete set of Neisseria meningitidis mutants and its use for the phenotypic profiling of this human pathogen.Nature communications · 2020Article
- Interstrain Cooperation in Meningococcal Biofilms: Role of Autotransporters NalP and AutA.Frontiers in microbiology · 2017Article
- Biological Functions of the Secretome ofFrontiers in cellular and infection microbiology · 2017Review
- Two-Partner Secretion: Combining Efficiency and Simplicity in the Secretion of Large Proteins for Bacteria-Host and Bacteria-Bacteria Interactions.Frontiers in cellular and infection microbiology · 2017Review
- Meningococcal Two-Partner Secretion Systems and Their Association with Outcome in Patients with Meningitis.Infection and immunity · 2016Article
- Structure-function analysis reveals that the Pseudomonas aeruginosa Tps4 two-partner secretion system is involved in CupB5 translocation.Protein science : a publication of the Protein Society · 2015Article
- A new family of secreted toxins in pathogenic Neisseria species.PLoS pathogens · 2015Article
- The polypeptide transport-associated (POTRA) domains of TpsB transporters determine the system specificity of two-partner secretion systems.The Journal of biological chemistry · 2014Article
- Domain exchange at the 3' end of the gene encoding the fratricide meningococcal two-partner secretion protein A.BMC genomics · 2013Article
- The biology of Neisseria adhesins.Biology · 2013Article
- System specificity of the TpsB transporters of coexpressed two-partner secretion systems of Neisseria meningitidis.Journal of bacteriology · 2013Article
- Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein.Clinical and vaccine immunology : CVI · 2011Article
- Virulence evolution of the human pathogen Neisseria meningitidis by recombination in the core and accessory genome.PloS one · 2011Article
- Protein Secretion Systems in Pseudomonas aeruginosa: An Essay on Diversity, Evolution, and Function.Frontiers in microbiology · 2011Article
- Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06.BMC genomics · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The two-partner secretion (TPS) pathway is widespread among gram-negative bacteria and facilitates the secretion of very large and often virulence-related proteins. TPS systems consist of a secreted TpsA protein and a TpsB protein involved in TpsA transport across the outer membrane. Sequenced Neisseria meningitidis genomes contain up to five TpsA- and two TpsB-encoding genes. Here, we investigated the distribution of TPS-related open reading frames in a collection of disease isolates. Three distinct TPS systems were identified among meningococci. System 1 was ubiquitous, while systems 2 and 3 were significantly more prevalent among isolates of hyperinvasive clonal complexes than among isolates of poorly invasive clonal complexes. In laboratory cultures, systems 1 and 2 were expressed. However, several sera from patients recovering from disseminated meningococcal disease recognized the TpsAs of systems 2 and 3, indicating the expression of these systems during infection. Furthermore, we showed that the major secreted TpsAs of systems 1 and 2 depend on their cognate TpsBs for transport across the outer membrane and that the system 1 TpsAs undergo processing. Together, our data indicate that TPS systems may contribute to the virulence of N. meningitidis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.