ArticleDiabetes2008
Oxidative stress regulates adipocyte apolipoprotein e and suppresses its expression in obesity.
Article in Diabetes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Comparison of effects of simvastatin versus atorvastatin on oxidative stress in patients with coronary heart disease.Clinical cardiology · 2010Trial
- IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Beyond the CNS: The many peripheral roles of APOE.Neurobiology of disease · 2020Review
- Comparative Proteomic Analysis of Serum from Pigs Experimentally Infected withPathogens (Basel, Switzerland) · 2020Article
- Pharmacologic concentrations of linezolid modify oxidative phosphorylation function and adipocyte secretome.Redox biology · 2017Article
- Selective suppression of adipose tissue apoE expression impacts systemic metabolic phenotype and adipose tissue inflammation.Journal of lipid research · 2015Article
- Capillary electrophoretic analysis of hydroxyl radicals produced by respiring mitochondria.Analytical and bioanalytical chemistry · 2013Article
- Low-fat dairy, but not whole-/high-fat dairy, consumption is related with higher serum adiponectin levels in apparently healthy adults.European journal of nutrition · 2013Article
- Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes.Journal of lipid research · 2013Article
- Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes.The Journal of endocrinology · 2013Article
- Adipose tissue: friend or foe?Nature reviews. Cardiology · 2012Review
- Adipose tissue depot-specific differences in adipocyte apolipoprotein E expression.Metabolism: clinical and experimental · 2011Article
- Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis.Journal of lipid research · 2011Article
- Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane.Journal of lipid research · 2011Article
- Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?Archives of medical science : AMS · 2011Article
- Hyperglycemia and advanced glycosylation end products suppress adipocyte apoE expression: implications for adipocyte triglyceride metabolism.American journal of physiology. Endocrinology and metabolism · 2010Article
- Gamma-oryzanol rich fraction regulates the expression of antioxidant and oxidative stress related genes in stressed rat's liver.Nutrition & metabolism · 2010Article
- Mechanism for endogenously expressed ApoE modulation of adipocyte very low density lipoprotein metabolism: role in endocytic and lipase-mediated metabolic pathways.The Journal of biological chemistry · 2009Article
- Role of adipocyte-derived apoE in modulating adipocyte size, lipid metabolism, and gene expression in vivo.American journal of physiology. Endocrinology and metabolism · 2009Article
- Peroxisome proliferator-activated receptor {gamma} stimulation of adipocyte ApoE gene transcription mediated by the liver receptor X pathway.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveEndogenous expression of apolipoprotein E (apoE) has a significant impact on adipocyte lipid metabolism and is markedly suppressed in obesity. Adipose tissue oxidant stress is emerging as an important mediator of adipocyte dysfunction. These studies were undertaken to evaluate the role of oxidant stress for regulation of adipocyte apoE. RESEARCH DESIGN AND
methodsApoE gene and protein expression in 3T3-L1 adipocytes or mature adipocytes and adipose tissue from C57/BL6 mice was evaluated after induction of oxidant stress. The response of adipose tissue and adipocytes from obese compared with lean mice to antioxidants was also assessed.
resultsOxidant stress in 3T3-L1 cells or adipocytes and adipose tissue from lean mice significantly reduced apoE mRNA and protein level. Inclusion of an antioxidant eliminated this reduction. Oxidant stress was accompanied by activation of the nuclear factor-kappaB (NF-kappaB) transcription complex, and its effect on apoE was eliminated by an NF-kappaB activation inhibitor. Treatment of freshly isolated adipose tissue or mature adipocytes from obese mice with antioxidant increased apoE expression but had no effect on cells or tissue from lean mice. Incubation of freshly isolated adipocytes from lean mice with stromovascular cells from obese mice significantly suppressed adipocyte apoE compared with incubation with stromovascular cells from lean mice, but this suppression was reversed by inclusion of antioxidant or a neutralizing antibody to tumor necrosis factor-alpha.
conclusionsOxidant stress significantly modulates adipose tissue and adipocyte apoE expression. Furthermore, oxidant stress contributes to suppression of adipocyte apoE in obesity. This suppression depends on interaction between adipose tissue stromovascular cells and adipocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.