ReviewCurrent opinion in chemical biology2008
The impact of enzyme engineering upon natural product glycodiversification.
Review in Current opinion in chemical biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 92 citations in OpenAlex.
- Transcriptomic analysis and carbohydrate metabolism-related enzyme expression across different pH values inFrontiers in microbiology · 2024Article
- Validation of a metabolite-GWAS network forFrontiers in plant science · 2023Article
- Rhamnose-Containing Compounds: Biosynthesis and Applications.Molecules (Basel, Switzerland) · 2022Review
- Cell-based high-throughput screening of polysaccharide biosynthesis hosts.Microbial cell factories · 2021Review
- GDP-Mannose 3,5-Epimerase: A View on Structure, Mechanism, and Industrial Potential.Frontiers in molecular biosciences · 2021Review
- Comparative Analysis of High-Throughput Assays of Family-1 Plant Glycosyltransferases.International journal of molecular sciences · 2020Article
- Glycosyltransferase GT1 family: Phylogenetic distribution, substrates coverage, and representative structural features.Computational and structural biotechnology journal · 2020Review
- Engineering Heterologous Production of Salicylate Glucoside and Glycosylated Variants.Frontiers in microbiology · 2018Article
- Biosynthesis of three N-acetylaminosugar-conjugated flavonoids using engineered Escherichia coli.Microbial cell factories · 2016Article
- Engineering Saccharomyces cerevisiae with the deletion of endogenous glucosidases for the production of flavonoid glucosides.Microbial cell factories · 2016Article
- One-pot multienzyme (OPME) systems for chemoenzymatic synthesis of carbohydrates.Organic & biomolecular chemistry · 2016Article
- Glycosyltransferase engineering for carbohydrate synthesis.Biochemical Society transactions · 2016Review
- Bacterial Glycosyltransferases: Challenges and Opportunities of a Highly Diverse Enzyme Class Toward Tailoring Natural Products.Frontiers in microbiology · 2016Article
- Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A simple strategy for glycosyltransferase-catalyzed aminosugar nucleotide synthesis.Chembiochem : a European journal of chemical biology · 2014Article
- In vitro characterization of LmbK and LmbO: identification of GDP-D-erythro-α-D-gluco-octose as a key intermediate in lincomycin A biosynthesis.Journal of the American Chemical Society · 2014Article
- Leloir Glycosyltransferases and Natural Product Glycosylation: Biocatalytic Synthesis of theAdvanced synthesis & catalysis · 2013Article
- pH-rate profiles support a general base mechanism for galactokinase (Lactococcus lactis).FEBS letters · 2013Article
- Functional screening of metagenome and genome libraries for detection of novel flavonoid-modifying enzymes.Applied and environmental microbiology · 2013Article
- Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN.Journal of the American Chemical Society · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Glycodiversification of natural products is an effective strategy for small molecule drug development. Recently, improved methods for chemo-enzymatic synthesis of glycosyl donors has spurred the characterization of natural product glycosyltransferases (GTs), revealing that the substrate specificity of many naturally occurring GTs as too stringent for use in glycodiversification. Protein engineering of natural product GTs has emerged as an attractive approach to overcome this limitation. This review highlights recent progress in the engineering/evolution of enzymes relevant to natural product glycodiversification with a particular focus upon GTs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.