ReviewChromosoma2008
Bi-orienting chromosomes: acrobatics on the mitotic spindle.
Review in Chromosoma, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Acentric chromosome congression and alignment on the metaphase plate via kinetochore-independent forces.Genetics · 2025Article
- Principles and dynamics of spindle assembly checkpoint signalling.Nature reviews. Molecular cell biology · 2023Review
- The chirality of the mitotic spindle provides a mechanical response to forces and depends on microtubule motors and augmin.Current biology : CB · 2022Article
- Aurora B Tension Sensing Mechanisms in the Kinetochore Ensure Accurate Chromosome Segregation.International journal of molecular sciences · 2021Review
- Chromosomal attachments set length and microtubule number in the Saccharomyces cerevisiae mitotic spindle.Molecular biology of the cell · 2014Article
- Tethering sister centromeres to each other suggests the spindle checkpoint detects stretch within the kinetochore.PLoS genetics · 2014Article
- Review
- Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis.Molecular biology of the cell · 2012Article
- Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint.Cell proliferation · 2011Review
- Article
- Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1.PloS one · 2011Article
- CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.The EMBO journal · 2011Article
- Kinetochore-microtubule interactions: steps towards bi-orientation.The EMBO journal · 2010Review
- Article
- Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres.Genes & development · 2010Article
- Kinetochores: orchestrating the chromosomal minuet.Current biology : CB · 2010Article
- Live-cell analysis of kinetochore-microtubule interaction in budding yeast.Methods (San Diego, Calif.) · 2010Review
- Kinetochores generate microtubules with distal plus ends: their roles and limited lifetime in mitosis.Developmental cell · 2010Article
- Ipl1-dependent phosphorylation of Dam1 is reduced by tension applied on kinetochores.Journal of cell science · 2009Article
- Chromosome segregation machinery and cancer.Cancer science · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
To maintain their genetic integrity, eukaryotic cells must segregate their chromosomes properly to opposite poles during mitosis. This process mainly depends on the forces generated by microtubules that attach to kinetochores. During prometaphase, kinetochores initially interact with a single microtubule that extends from a spindle pole and then move towards a spindle pole. Subsequently, microtubules that extend from the other spindle pole also interact with kinetochores and, eventually, each sister kinetochore attaches to microtubules that extend from opposite poles (sister kinetochore bi-orientation). If sister kinetochores interact with microtubules in wrong orientation, this must be corrected before the onset of anaphase. Here, I discuss the processes leading to bi-orientation and the mechanisms ensuring this pivotal state that is required for proper chromosome segregation.
Indexed as
Identifiers
18677502What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.