ReviewJournal of molecular neuroscience : MN2008
The role of vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide in the neural pathways controlling the lower urinary tract.
Review in Journal of molecular neuroscience : MN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Neuropeptides and the Autonomic Nervous System in Prader-Willi Syndrome.International journal of molecular sciences · 2025Review
- Aging-related NADPH diaphorase positive neurodegenerations in the sacral spinal cord of aged non-human primates.Scientific reports · 2024Article
- De novo aging-related NADPH diaphorase positive megaloneurites in the sacral spinal cord of aged dogs.Scientific reports · 2023Article
- Bisphenol A Effects on Neurons' Neurochemical Character in the Urinary Bladder Intramural Ganglia of Domestic Pigs.International journal of molecular sciences · 2023Article
- Effects of electroacupuncture on bladder dysfunction and the expression of PACAP38 in a diabetic rat model.Frontiers in physiology · 2022Article
- Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone.Scientific reports · 2021Article
- The Influence of an Adrenergic Antagonist Guanethidine on the Distribution Pattern and Chemical Coding of Caudal Mesenteric Ganglion Perikarya and Their Axons Supplying the Porcine Bladder.International journal of molecular sciences · 2021Article
- Maternal Fructose Exposure Programs Metabolic Syndrome-Associated Bladder Overactivity in Young Adult Offspring.Scientific reports · 2016Article
- The Role of the Mucosa in Normal and Abnormal Bladder Function.Basic & clinical pharmacology & toxicology · 2016Review
- Examination of PACAP-Like Immunoreactivity in Urogenital Tumor Samples.Journal of molecular neuroscience : MN · 2016Article
- Research Findings on Overactive Bladder.Current urology · 2015Review
- Neural control of the lower urinary tract.Comprehensive Physiology · 2015Review
- Localization of peripheral autonomic neurons innervating the boar urinary bladder trigone and neurochemical features of the sympathetic component.European journal of histochemistry : EJH · 2013Article
- Remote control of renal physiology by the intestinal neuropeptide pigment-dispersing factor in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Plasticity in reflex pathways to the lower urinary tract following spinal cord injury.Experimental neurology · 2012Review
- Pituitary adenylate cyclase-activating polypeptide is protective against oxidative stress in human retinal pigment epithelial cells.Journal of molecular neuroscience : MN · 2011Article
- Neuropeptides in lower urinary tract function.Handbook of experimental pharmacology · 2011Review
- Mechanisms of action of sacral neuromodulation.International urogynecology journal · 2010Review
- Effects of PACAP on mitochondrial apoptotic pathways and cytokine expression in rats subjected to renal ischemia/reperfusion.Journal of molecular neuroscience : MN · 2010Article
- Effect of Salvia miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced digestive tract congestion.Frontiers of medicine in China · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are expressed in the neural pathways regulating the lower urinary tract. VIP-immunoreactivity (IR) is present in afferent and autonomic efferent neurons innervating the bladder and urethra, whereas PACAP-IR is present primarily in afferent neurons. Exogenously applied VIP relaxes bladder and urethral smooth muscle and excites parasympathetic neurons in bladder ganglia. PACAP relaxes bladder and urethral smooth muscle in some species (pig) but excites the smooth muscle in other species (mouse). Intrathecal administration of VIP in cats with an intact spinal cord suppresses reflex bladder activity, but intrathecal administration of VIP or PACAP in rats enhances bladder activity and suppresses urethral sphincter activity. PACAP has presynaptic facilitatory effects and direct excitatory effects on lumbosacral parasympathetic preganglionic neurons. Chronic spinal cord transection produces an expansion of VIP-IR (cats) and PACAP-IR (rats) in primary afferent axons in the lumbosacral spinal cord and unmasks spinal excitatory effects of VIP on bladder reflexes in cats. Intrathecal administration of PACAP6-38, a PAC1 receptor antagonist, reduces bladder hyperactivity in chronic spinal-cord-injured rats. These observations raise the possibility that VIP or PACAP have a role in the control of normal or abnormal voiding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.