ArticleOptometry and vision science : official publication of the American Academy of Optometry2008
Dry eye and designer ophthalmics.
Article in Optometry and vision science : official publication of the American Academy of Optometry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium.International journal of molecular sciences · 2020Article
- The Anti-Inflammatory Effects of Angiogenin in an Endotoxin Induced Uveitis in Rats.International journal of molecular sciences · 2020Article
- Analysis of cross-population differentiation between Thoroughbred and Jeju horses.Asian-Australasian journal of animal sciences · 2018Article
- A thermo-responsive protein treatment for dry eyes.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Practical issues concerning tear protein assays in dry eye.Eye and vision (London, England) · 2014Review
- Lacritin and the tear proteome as natural replacement therapy for dry eye.Experimental eye research · 2013Review
- Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.The Journal of biological chemistry · 2013Article
- Conserved regional 3' grouping of rare codons in the coding sequence of ocular prosecretory mitogen lacritin.Investigative ophthalmology & visual science · 2013Article
- Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity.Investigative ophthalmology & visual science · 2013Article
- Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated.Investigative ophthalmology & visual science · 2011Article
- Lacritin and other new proteins of the lacrimal functional unit.Experimental eye research · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Expressed sequence tag (EST), proteomic, and antibody capture assays are revealing a level of tear film protein complexity far greater than previously appreciated. A systems biology approach will be needed to fully appreciate function as tear protein doses fluctuate in time through different conditions. Although consensus is growing on what fully constitutes the human tear proteome, questions remain about the source and significance of the approximately 256 tear proteins designated as "intracellular." Many of these may derive from normal cellular turnover and could therefore be informative. A further >183 are designated as "extracellular." Surprisingly, only 4 to 5% of these appear to be dysregulated in the three forms of dry eye preliminarily examined to date. Some differ and a couple overlap, suggesting that disease-specific signatures could be identified. Future dry eye treatment might include recombinant tear protein rescue as a personalized ophthalmic approach to ocular surface disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.