Trial reportInternational journal of epidemiology2009
Maternal protein-energy supplementation does not affect adolescent blood pressure in The Gambia.
Trial report in International journal of epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Is birth weight associated with blood pressure among African children and adolescents? A systematic review.Journal of developmental origins of health and disease · 2018Pooled it
- Antenatal dietary education and supplementation to increase energy and protein intake.The Cochrane database of systematic reviews · 2015Pooled it
- Tackling malnutrition: a systematic review of 15-year research evidence from INDEPTH health and demographic surveillance systems.Global health action · 2015Pooled it
- Maternal-Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Affect Child Blood Pressure at 4-6 Y in Ghana: Follow-up of a Randomized Trial.The Journal of nutrition · 2019Trial
- Supplemental feeding during pregnancy compared with maternal supplementation during lactation does not affect schooling and cognitive development through late adolescence.The American journal of clinical nutrition · 2014Trial
- Combined food and micronutrient supplements during pregnancy have limited impact on child blood pressure and kidney function in rural Bangladesh.The Journal of nutrition · 2013Trial
- Trial
- Effects of prenatal early food and micronutrient supplementations on body size and cardiometabolic risk factors in the 15-year-old offspring - the MINIMat randomised trial.The Lancet regional health. Southeast Asia · 2026Article
- Prenatal factors shaping adolescent cardiovascular function and cardiometabolic risk trajectories.Frontiers in pediatrics · 2026Review
- Like mother like daughter, the role of low human capital in intergenerational cycles of disadvantage: the Pune Maternal Nutrition Study.Frontiers in global women's health · 2024Article
- Associations Between Maternal Nutrition in Pregnancy and Child Blood Pressure at 4-6 Years: A Prospective Study in a Community-Based Pregnancy Cohort.The Journal of nutrition · 2021Article
- The Pune Rural Intervention in Young Adolescents (PRIYA) study: design and methods of a randomised controlled trial.BMC nutrition · 2017Article
- Early life nutritional programming of health and disease in The Gambia.Journal of developmental origins of health and disease · 2016Review
- Birth weight, malnutrition and kidney-associated outcomes--a global concern.Nature reviews. Nephrology · 2015Review
- Early influences on cardiovascular and renal development.European journal of epidemiology · 2010Review
- Non-communicable diseases in low- and middle-income countries: context, determinants and health policy.Tropical medicine & international health : TM & IH · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundBirthweight, and by inference maternal nutrition during pregnancy, is thought to be an important determinant of offspring blood pressure but the evidence base for this in humans is lacking data from randomized controlled trials.
methodsThe offspring from a maternal prenatal protein-energy supplementation trial were enrolled into a follow-up study of chronic disease risk factors including blood pressure. Subjects were 11-17 years of age and blood pressure was measured in triplicate using an automated monitor (Omron 705IT). One-thousand two-hundred sixty seven individuals (71% of potential participants) were included in the analysis.
resultsThere was no difference in blood pressure between those whose mothers had consumed protein-energy biscuits during pregnancy and those whose mothers had consumed the same supplement post-partum. For systolic blood pressure the intention-to-treat regression coefficient was 0.46 (95% CI: -1.12, 2.04). Mean systolic blood pressure for control children was 110.2 (SD +/- 9.3) mmHg and for intervention children was 110.8 (SD +/- 8.8) mmHg. Mean diastolic blood pressure for control children was 64.7 (SD +/- 7.7) mmHg and for intervention children was 64.6 (SD +/- 7.6) mmHg.
conclusionsWe have found no association between maternal prenatal protein-energy supplementation and offspring blood pressure in adolescence amongst rural Gambians. We found some evidence to suggest that offspring body composition may interact with the effect of maternal supplementation on blood pressure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.