ArticleEukaryotic cell2008
Dissecting colony development of Neurospora crassa using mRNA profiling and comparative genomics approaches.
Article in Eukaryotic cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 73 citations in OpenAlex.
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- Syncytial Assembly Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis.Results and problems in cell differentiation · 2024Review
- Lineage-specific genes are clustered with HET-domain genes and respond to environmental and genetic manipulations regulating reproduction in Neurospora.PLoS genetics · 2023Article
- Phenotype to genotype inCurrent research in microbial sciences · 2022Article
- Quantitative single molecule RNA-FISH and RNase-free cell wall digestion in Neurospora crassa.Fungal genetics and biology : FG & B · 2021Article
- Mixed infections alter transmission potential in a fungal plant pathogen.Environmental microbiology · 2021Article
- Clustering analysis of large-scale phenotypic data in the model filamentous fungus Neurospora crassa.BMC genomics · 2020Article
- Syncytia in Fungi.Cells · 2020Review
- Asexual reproduction and growth rate: independent and plastic life history traits in Neurospora crassa.The ISME journal · 2019Article
- Functional distinction of hyphal compartments.Scientific reports · 2017Article
- The Adenylate-Forming Enzymes AfeA and TmpB Are Involved in Aspergillus nidulans Self-Communication during Asexual Development.Frontiers in microbiology · 2016Article
- Nuclear autonomy in multinucleate fungi.Current opinion in microbiology · 2015Review
- Global Analysis of Predicted G Protein-Coupled Receptor Genes in the Filamentous Fungus, Neurospora crassa.G3 (Bethesda, Md.) · 2015Article
- Switching from a unicellular to multicellular organization in an Aspergillus niger hypha.mBio · 2015Article
- Dynamics of the establishment of multinucleate compartments in Fusarium oxysporum.Eukaryotic cell · 2015Article
- Reproductive competence: a recurrent logic module in eukaryotic development.Proceedings. Biological sciences · 2013Review
- Cytosolic streaming in vegetative mycelium and aerial structures of Aspergillus niger.Studies in mycology · 2013Article
- The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.PLoS genetics · 2013Article
- Physiological significance of network organization in fungi.Eukaryotic cell · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Colony development, which includes hyphal extension, branching, anastomosis, and asexual sporulation, is a fundamental aspect of the life cycle of filamentous fungi; genetic mechanisms underlying these phenomena are poorly understood. We conducted transcriptional profiling during colony development of the model filamentous fungus Neurospora crassa, using 70-mer oligonucleotide microarrays. Relative mRNA expression levels were determined for six sections of defined age excised from a 27-h-old N. crassa colony. Functional category analysis showed that the expression of genes involved in cell membrane biosynthesis, polar growth, and cellular signaling was enriched at the periphery of the colony. The relative expression of genes involved in protein synthesis and energy production was enriched in the middle section of the colony, while sections of the colony undergoing asexual development (conidiogenesis) were enriched in expression of genes involved in protein/peptide degradation and unclassified proteins. A cross-examination of the N. crassa data set with a published data set of Aspergillus niger revealed shared patterns in the spatiotemporal regulation of gene orthologs during colony development. At present, less than 50% of genes in N. crassa have functional annotation, which imposes the chief limitation on data analysis. Using an evolutionary approach, we observed that the expression of phylogenetically conserved groups of genes was enriched in the middle section of an N. crassa colony whereas expression of genes unique to euascomycete species and of N. crassa orphan genes was enriched at the colony periphery and in the older, conidiating sections of a fungal colony.
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