ArticleCancer research2008
Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate.
Article in Cancer research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Temporal Transcriptomic Profiling of NMBA-Induced Rat Esophageal Squamous Carcinogenesis Identifies Early Inflammatory Activation and Late NRF2-Associated Oxidative-Stress Remodeling.International journal of molecular sciences · 2026Article
- Chemopreventive Properties of Black Raspberries and Strawberries in Esophageal Cancer Review.Antioxidants (Basel, Switzerland) · 2022Review
- Melatonin Alleviates Oxidative Stress Induced by HAntioxidants (Basel, Switzerland) · 2022Article
- A nutrigenetic approach for investigating the chemopreventive effects of black raspberries during the development of preneoplastic esophagi in rats.Journal of berry research · 2018Article
- Inhibition of the development of N-nitrosomethylbenzylamine-induced esophageal tumors in rats by strawberries and aspirin, alone and in combination.Journal of berry research · 2018Article
- Protective Role of Dietary Berries in Cancer.Antioxidants (Basel, Switzerland) · 2016Review
- Isothiocyanates: a class of bioactive metabolites with chemopreventive potential.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Chemoprevention of oral cancer by topical application of black raspberries on high at-risk mucosa.Oral surgery, oral medicine, oral pathology and oral radiology · 2014Article
- Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.Journal of the National Cancer Institute · 2011Article
- Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis.Carcinogenesis · 2011Article
- Dietary freeze-dried black raspberry's effect on cellular antioxidant status during reflux-induced esophagitis in rats.Nutrition (Burbank, Los Angeles County, Calif.) · 2011Article
- Black raspberries inhibit intestinal tumorigenesis in apc1638+/- and Muc2-/- mouse models of colorectal cancer.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats.Pharmaceutical research · 2010Article
- Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM.Carcinogenesis · 2010Article
- p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.Cancer research · 2010Article
- A rapid and sensitive LC-MS/MS method for quantification of four anthocyanins and its application in a clinical pharmacology study of a bioadhesive black raspberry gel.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2009Article
- Different redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol.Antioxidants & redox signaling · 2009Article
- Foodstuffs for preventing cancer: the preclinical and clinical development of berries.Cancer prevention research (Philadelphia, Pa.) · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Our recent study identified 2,261 dysregulated genes in the esophagi of rats that received a 1-week exposure to the carcinogen N-nitrosomethylbenzylamine (NMBA). We further reported that 1,323 of these genes were positively modulated to near-normal levels of expression in NMBA-treated animals that consumed dietary phenylethyl isothiocyanate (PEITC), a constituent of cruciferous vegetables. Herein, we report our results with companion animals that were fed a diet containing 5% freeze-dried black raspberries (BRB) instead of PEITC. We found that 462 of the 2,261 NMBA-dysregulated genes in rat esophagus were restored to near-normal levels of expression by BRB. Further, we have identified 53 NMBA-dysregulated genes that are positively modulated by both PEITC and BRB. These 53 common genes include genes involved in phase I and II metabolism, oxidative damage, and oncogenes and tumor suppressor genes that regulate apoptosis, cell cycling, and angiogenesis. Because both PEITC and BRB maintain near-normal levels of expression of these 53 genes, their dysregulation during the early phase of NMBA-induced esophageal cancer may be especially important in the genesis of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.