ArticleGenes & development2008
Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b.
Article in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Ethanol Alters DNMT1/3a/3b Expression Profile, Promotes Persistent DNA Hypomethylation in Human Brain Endothelial Cells and Impairs Late Cortical Angiogenesis.Journal of neurochemistry · 2026Article
- The Multifaceted Roles of Zinc Finger Proteins in Pluripotency and Reprogramming.International journal of molecular sciences · 2025Review
- Epigenetic Regulation of Mammalian Cardiomyocyte Development.Epigenomes · 2024Review
- Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression.Cell reports · 2023Article
- ETV2 and VEZF1 interaction and regulation of the hematoendothelial lineage during embryogenesis.Frontiers in cell and developmental biology · 2023Article
- VEZF1-guanine quadruplex DNA interaction regulates alternative polyadenylation and detyrosinase activity of VASH1.Nucleic acids research · 2020Article
- Vezf1 regulates cardiac structure and contractile function.EBioMedicine · 2020Article
- The transcription factor Vezf1 represses the expression of the antiangiogenic factor Cited2 in endothelial cells.The Journal of biological chemistry · 2018Article
- Characterization of Small Molecules Inhibiting the Pro-Angiogenic Activity of the Zinc Finger Transcription Factor Vezf1.Molecules (Basel, Switzerland) · 2018Article
- Testicular Dnmt3 expression and global DNA methylation are down-regulated by gonadotropin releasing hormones in the ricefield eel Monopterus albus.Scientific reports · 2017Article
- Yeast one-hybrid screen of a thymus epithelial library identifies ZBTB7A as a regulator of thymic insulin expression.Molecular immunology · 2013Article
- Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.Human molecular genetics · 2013Article
- Chromatin domains, insulators, and the regulation of gene expression.Biochimica et biophysica acta · 2012Review
- Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma.Epigenetics · 2011Article
- Endothelin-1 gene regulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Review
- Association between acquired uniparental disomy and homozygous mutations and HER2/ER/PR status in breast cancer.PloS one · 2010Article
- Poly(ADP-ribose) polymerase-1 (PARP-1) contributes to the barrier function of a vertebrate chromatin insulator.The Journal of biological chemistry · 2010Article
- Article
- Targeted Vezf1-null mutation impairs vascular structure formation during embryonic stem cell differentiation.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The zinc finger protein vascular endothelial zinc finger 1 (Vezf1) has been implicated in the development of the blood vascular and lymphatic system in mice, and has been characterized as a transcriptional activator in some systems. The chicken homolog, BGP1, has binding sites in the beta-globin locus, including the upstream insulator element. We report that in a mouse embryonic stem cell line deletion of both copies of Vezf1 results in loss of DNA methylation at widespread sites in the genome, including Line1 elements and minor satellite repeats, some imprinted genes, and several CpG islands. Loss of methylation appears to arise from a substantial decrease in the abundance of the de novo DNA methyltransferase, Dnmt3b. These results suggest that naturally occurring mutations in Vezf1/BGP1 might have widespread effects on DNA methylation patterns and therefore on epigenetic regulation of gene expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.