ArticleJournal of dental education2008
Whole-tooth regeneration: it takes a village of scientists, clinicians, and patients.
Article in Journal of dental education, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Biomechanical and Bio-Inspired Perspectives on Root Amputation in Maxillary Molars: An FEA Study.Biomimetics (Basel, Switzerland) · 2025Article
- Subcutaneous implantation of tooth germ stem cells over the masseter muscle in mice: An in vivo pilot study.Regenerative therapy · 2025Article
- The cell re-association-based whole-tooth regeneration strategies in large animal, Sus scrofa.Cell proliferation · 2018Article
- Recombinant Amelogenin Protein Induces Apical Closure and Pulp Regeneration in Open-apex, Nonvital Permanent Canine Teeth.Journal of endodontics · 2016Article
- Osteogenic differentiation and gene expression profile of human dental follicle cells induced by human dental pulp cells.Journal of molecular histology · 2015Article
- Influence of nanotopography on periodontal ligament stem cell functions and cell sheet based periodontal regeneration.International journal of nanomedicine · 2015Article
- The epithelial-mesenchymal interactions: insights into physiological and pathological aspects of oral tissues.Oncology reviews · 2014Review
- Tooth tissue engineering: the influence of hydrophilic surface on nanocrystalline diamond films for human dental stem cells.Tissue engineering. Part A · 2013Article
- Tooth auto-transplantation as an alternative treatment option: A literature review.Dental research journal · 2013Article
- Stem cell therapy in oral and maxillofacial region: An overview.Journal of oral and maxillofacial pathology : JOMFP · 2012Article
- Where is dentistry in regenerative medicine?International dental journal · 2011Review
- Potential feasibility of dental stem cells for regenerative therapies: stem cell transplantation and whole-tooth engineering.Odontology · 2011Review
- Biological synthesis of tooth enamel instructed by an artificial matrix.Biomaterials · 2010Article
- The REGENERATION of TOOTH ENAMEL.Dimensions of dental hygiene · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
A team of senior scientists was formed in 2006 to create a blueprint for the regeneration of whole human teeth along with all of the supporting structure of the dentition. The team included experts from diverse fields, each with a reputation for stellar accomplishment. Participants attacked the scientific issues of tooth regeneration but, more importantly, each agreed to work collaboratively with experts from other disciplines to form a learning organization. A commitment to learn from one another produced a unique interdisciplinary and multidisciplinary team. Inspired by the Kennedy space program to send a man to the moon, with its myriad of problems and solutions that no one discipline could solve, this tooth regeneration team devised an ambitious plan that sought to use stem cell biology, engineering, and computational biology to replicate the developmental program for odontogenesis. In this manner, team members envisioned a solution that consisted of known or knowable fundamentals. They proposed a laboratory-grown tooth rudiment that would be capable of executing the complete program for odontogenesis when transplanted to a suitable host, recreating all of the dental tissues, periodontal ligament, cementum, and alveolar bone associated with the canonical tooth. This plan was designed to bring regenerative medicine fully into the dental surgery suite, although a lack of funding has so far prevented the plan from being carried out.
Indexed as
Identifiers
18676799PMC2546443W2099429950What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.