ArticleClinical cancer research : an official journal of the American Association for Cancer Research2008
Genetic polymorphisms of metastasis suppressor gene NME1 and breast cancer survival.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Common germline polymorphisms associated with breast cancer-specific survival.Breast cancer research : BCR · 2015Pooled it
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- Nonmetastatic cell 1 gene polymorphisms are associated with the clinical progression and prognoses of patients with colorectal cancer.Frontiers in genetics · 2025Article
- NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer.Journal of the Egyptian National Cancer Institute · 2024Article
- A review of genetic variant databases and machine learning tools for predicting the pathogenicity of breast cancer.Briefings in bioinformatics · 2023Review
- Association of NM23 polymorphisms and clinicopathological features and recurrence of invasive pituitary adenomas.Pituitary · 2020Article
- The Origin of a Coastal Indigenous Horse Breed in China Revealed by Genome-Wide SNP Data.Genes · 2019Article
- Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML).Journal of translational medicine · 2018Article
- Single nucleotide variants in metastasis-related genes are associated with breast cancer risk, by lymph node involvement and estrogen receptor status, in women with European and African ancestry.Molecular carcinogenesis · 2017Article
- Risk Factors and Preventions of Breast Cancer.International journal of biological sciences · 2017Review
- Association between nm23 gene polymorphisms and the risk of endometriosis.Biomedical reports · 2015Article
- Prediction of disease genes using tissue-specified gene-gene network.BMC systems biology · 2014Article
- Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data.Proceedings. IEEE International Symposium on Bioinformatics and Bioengineering · 2013Article
- Plakoglobin represses SATB1 expression and decreases in vitro proliferation, migration and invasion.PloS one · 2013Article
- The relationship between eight GWAS-identified single-nucleotide polymorphisms and primary breast cancer outcomes.The oncologist · 2013Article
- Associations of non-metastatic cells 1 gene polymorphisms with lymph node metastasis risk of gastric cancer in Northern Chinese population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Metastasis-suppressor genes in clinical practice: lost in translation?Nature reviews. Clinical oncology · 2011Review
- Article
- Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China.BMC cancer · 2009Article
- Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study.Breast cancer research : BCR · 2009Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeAmple evidence supports an important role of tumor metastasis suppressor genes in cancer metastatic processes. We evaluated the association of genetic polymorphisms of metastasis suppressor gene NME1 with breast cancer prognosis in a follow-up study of patients with primary breast cancer and further investigated the functions of these polymorphisms. EXPERIMENTAL
designNME1 genotypes were analyzed in a cohort of 1,134 breast cancer patients recruited as part of the Shanghai Breast Cancer Study who were followed for a median of 7.1 years. In vitro biochemical analyses were carried out to examine the function of NME1 gene polymorphisms.
resultsSingle nucleotide polymorphisms (SNP) in the promoter region of the NME1 gene were found to be associated with breast cancer prognosis. Patients carrying the C allele in rs16949649 were associated with higher breast cancer-specific mortality [hazard ratio (HR), 1.4; 95% confidence interval (95% CI), 1.1-1.9] compared with those carrying the wild-type allele, and the association was more evident in patients with an early-stage cancer (HR, 1.7; 95% CI, 1.2-2.5). SNP rs2302254 was also associated with breast cancer prognosis, and the association was statistically significant for the risk of breast cancer relapse, metastasis, and death (HR, 1.3; 95% CI, 1.0-1.6). In vitro biochemical analyses showed that minor alleles in rs2302254 and rs3760468, which is in strong linkage disequilibrium with rs16949646, altered nuclear proteins binding capacity and reduced NME1 promoter activity, supporting the results from an association study of these SNPs with breast cancer survival.
conclusionPromoter polymorphisms in the NME1 gene may alter its expression and influence breast cancer survival.
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